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Short-Term Influence of Caffeine and Medium-Chain Triglycerides on Ketogenesis: A Controlled Double-Blind Intervention Study

  • Background. Ketone bodies are a highly relevant topic in nutrition and medicine. -e influence of medium-chain triglycerides (MCT) on ketogenesis is well known and has been successfully used in ketogenic diets for many years. Nevertheless, the effects of MCTs and coconut oil on the production of ketone bodies have only partially been investigated. Furthermore, the increased mobilisation of free fatty acids and release of catabolic hormones by caffeine suggest an influence of caffeine on ketogenesis. Methods. In a controlled, double-blind intervention study, seven young healthy subjects received 10mL of tricaprylin (C8), tricaprin (C10), C8/C10 (50% C8, 50% C10), or coconut oil with or without 150 mg of caffeine, in 250mL of decaffeinated coffee, over ten interventions. At baseline and after every 40 minutes, for 4 h, ßHB and glucose in capillary blood as well as caffeine in saliva were measured. Furthermore, questionnaires were used to survey sensory properties, side effects, and awareness of hunger and satiety. Results. -e interventions with caffeine caused an increase in ßHB levels—in particular, the interventions with C8 highly impacted ketogenesis. -e effect decreased with increased chain lengths. All interventions showed a continuous increase in hunger and diminishing satiety. Mild side effects (total � 12) occurred during the interventions. Conclusions. -e present study demonstrated an influence of caffeine and MCTon ketogenesis. -eaddition of caffeine showed an additive effect on the ketogenic potential of MCT and coconut oil. C8 showed the highest ketogenicity.
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Author:Anna Baumeister, Joachim Gardemann, Manfred Fobker, Verena Spiegler, Tobias Fischer
DOI of original publication:https://doi/org/10.1155/2021/1861567
Parent Title (English):Hindawi Journal of Nutrition and Metabolism
Document Type:Article
Date of Publication (online):2021/06/17
Year of first Publication:2021
Provider of the Publication Server:FH Münster - University of Applied Sciences
Release Date:2021/06/17
Tag:Caffeine; Ketogenesis
Volume:Volume 2021, Article ID 1861567
First Page:1
Last Page:9
Faculties:Oecotrophologie · Facility Management (OEF)
Kompetenzzentrum Humanitäre Hilfe
open_access (DINI-Set):open_access
Fischer, Tobias
Licence (German):License LogoCreative Commons - Namensnennung (CC BY 4.0)