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Abstract
Purpose
Chronic health conditions and impaired quality of life are commonly experienced in childhood cancer survivors. While rehabilitation clinics support patients in coping with the disease, studies evaluating an inpatient rehabilitation program on promoting physical activity (PA) and health-related quality of life (HRQoL) are missing.
Methods
A 4-week inpatient rehabilitation program was prospectively evaluated. One hundred fifty patients with leukemia or lymphoma (N = 86), brain tumors (N = 38), and sarcomas (N = 26) were enrolled on average 17 months after cessation of acute medical treatment. PA amount and cadence (indicating the intensity of walking activity) using the StepWatch™ 3 Activity Monitor and HRQoL global and physical well-being scores using the KINDL® questionnaire were assessed before, immediately after, and 6 and 12 months following the program and analyzed using multiple linear mixed models.
Results
Significant effects on PA were only found at 12-month follow-up for amount and cadence variables (all p < 0.05). While leukemia and lymphoma patients revealed the highest PA level throughout the study, rehabilitation effects were more pronounced for cadence variables in brain tumor and sarcoma patients. The rehabilitation program had immediate (t = 4.56, p < 0.001) and sustainable effects on HRQoL global scores (6-month follow-up, t = 4.08, p < 0.001; 12-month follow-up, t = 3.13, p < 0.006).
Conclusions
Immediate and sustainable increases in HRQoL indicate that a 4-week rehabilitation program is beneficial for improving psychosocial well-being, while the significant increase in PA levels could be related to general recovery as well. The lack of a control group hampers the evaluation of the rehabilitation program on promoting PA levels in pediatric cancer patients.
Innovative Photoreaktoren in der Reaktionstechnik zur Wertstoffgewinnung und Abwasserbehandlung
(2016)
Different methods for optimization the anaerobic digestion (AD) of sugarcane filter cake (FC) with a special focus on volatile fatty acids (VFA) production were studied. Sodium hydroxide (NaOH) pretreatment at different concentrations was investigated in batch experiments and the cumulative methane yields fitted to a dual-pool two-step model to provide an initial assessment on AD. The effects of nitrogen supplementation in form of urea and NaOH pretreatment for improved VFA production were evaluated in a semi-continuously operated reactor as well. The results indicated that higher NaOH concentrations during pretreatment accelerated the AD process and increased methane production in batch experiments. Nitrogen supplementation resulted in a VFA loss due to methane formation by buffering the pH value at nearly neutral conditions (∼6.7). However, the alkaline pretreatment with 6 g NaOH/100 g FCFM improved both the COD solubilization and the VFA yield by 37%, mainly consisted by n-butyric and acetic acids.
Ergonomie und Usability
(2016)
Sediment Bypass Tunnels are operated to divert sediment around reservoirs reducing reservoir sedimentation. A major drawback of these tunnels is severe invert abrasion due to high velocity and sediment flows. There is an urgent need to establish innovative measurement systems of sediment transport rates in SBTs. In this paper, three bedload measuring systems, namely hydrophones, geophones, and newly developed plate microphones are introduced and compared. The Koshibu SBT is planned to operate from 2016. Plate microphones combined with geophones and other planned systems are installed in the tunnel. Results of preliminary tests and installation plans of bedload
measurement are presented.
Positive effects of reservoir sedimentation management on reservoir life: Examples from Japan
(2016)
The effectiveness of different strategies against reservoir sedimentation is demonstrated herein using data sets of Asahi, Nunobiki and Dashidaira reservoirs in Japan. The applied strategies encompass
sediment routing with a bypass tunnel, drawdown flushing during floods and sabo dam construction in the catchment. It is shown that bypassing and flushing are very efficient strategies enlarging reservoir life by 3 to 21 times up to many hundreds of years. Furthermore, it is revealed that also efforts in the catchment, e.g. sabo dam construction, is effective enlarging reservoir life by 2.4 times.
To understand the effects of sediment bypass on environmental recovery of the degraded channels below dams, bed topography and bed materials above and below dam reaches were surveyed by ground-based measurements and aerial photos using quadrocopter. Coarse bed materials such as boulders were more represented below than above the Koshibu dam, where the bypass tunnel had not been in operation yet. The coarse materials formed steps and protruded in the water column within riffles and runs, both of which can increase slow-flow areas, below the dam. On the other hand, sand, gravel, and cobbles were abundant below as much as above the Asahi dam, where the bypass tunnel had been operated for >17 years. The downstream environment in terms of bed topography and grain size seems to have almost been recovered for the Asahi dam. However, less representation of large cobbles and boulders below the dam suggested a possibility of a selective deposition of coarse materials at the upstream of the bypass tunnel inlet.
For long term use of dams, it is required to develop methods of sediment management in reservoirs.
As one method, Sediment BypassTunnels (SBT) are operated in Japan and Switzerland to prevent reservoir sedimentation. SBT reduces sedimentation in reservoirs by routing the incoming sediments around the dam. SBT, however, is prone to severe invert abrasion caused by high sediment flux. Therefore, it is necessary to establish a measurement system of sediment transport rates in the SBT. A geophone was experimentally investigated in a laboratory flume at ETH Zurich. The sediment transport rate is calculated based on the plate vibration caused by hitting of gravels. In this paper, in order to alleviate disadvantages of a geophone, two newly developed sensor systems, a plate microphone and plate vibration sensor, are suggested and the results of their calibration experiments are shown. Finally, they are compared with the existing methods.
Sediment, which deposits and damages the function of reservoirs, is an essential element of aquatic habitats in downstream ecosystems. We reviewed ecosystem features of degraded channels associated with sediment deficiency below dams and ecosystem responses to changes in sediment conditions after management practices in Japan. Sediment bypass tunnel (SBT) is an effective way to transport sufficient amount of sediment to downstream ecosystems. Based on a concept of suitable mass and size of sediment for ecosystem, some effects and limitations of SBT on downstream ecosystems were discussed.
Sediment bypass tunnels are an effective and sustainable strategy against reservoir sedimentation. Sediments are diverted into the down-stream during floods without deposition in the reservoir, hence mor-phological and ecological variability increases. One major drawback of these tunnels is the severe invert abrasion due to a combination of high flow velocities and bedload sediment transport. The abrasion phenom-ena is briefly described, different abrasion prediction models are pre-sented and their applicability for the estimation of concrete abrasion is discussed.
In the new media environment, how are bodies and images related? How can, in other words, the human body be integrated with and reformulated in relation to the sensory and perceptual dimension? In response to this question, Image Embodiment looks not just to images and surface appearences but addresses at a deeper level the media that act as the supports for aesthetics. To think about visual culture in the twenty-first century necessarily implies the thinking of the specific role of media technologies. A view to media not only teases out the technical infrastructure of images but brings with it the potential for addressing the different sense modalities and realities of the human body. Recent theories of the sensory turn are effectively highlighting innovative approaches for an autonomous image science and media theory in general. Image Embodiment provides one part of the discourse to synchronize the concepts of image and body, which is then able to connect the perspectives of philosophy of mind, perceptual theory and media as well as image science. This volume monitors and discusses the relation of media and the human body and refers to images, embodiment and the sensory turn within the perspective of an autonomous image science.
From a thin film model for passive suspensions towards the description of osmotic biofilm spreading
(2016)
BACKGROUND Concerns about the nutritional status of Cambodian garment workers were raised years ago but data are still scarce. The objectives of this study are to examine the nutritional, hemoglobin and micronutrient status of female workers in a garment factory in Phnom Penh, Cambodia, and to assess if body mass index is associated with hemoglobin and/or micronutrient status. METHODS A cross-sectional survey was conducted among 223 female workers (nulliparous, non-pregnant) at a garment factory in Phnom Penh. Anthropometric measurements were performed and blood samples were taken to obtain results on hemoglobin, iron, vitamin A, vitamin B12 and inflammation status (hemoglobinopathies not determined). Bivariate correlations were used to assess associations. RESULTS Overall, 31.4% of workers were underweight, 26.9% showed anemia, 22.1% showed iron deficiency, while 46.5% had marginal iron stores. No evidence of vitamin A or vitamin B12 deficiency was found. Body mass index was associated with serum ferritin (negative) and serum retinol-binding protein (positive) concentrations, but not strongly. A comparison between underweight and not underweight workers resulted in distinctions for iron deficiency and iron deficiency anemia, with a higher prevalence among not underweight. CONCLUSIONS The prevalence of underweight, anemia and poor iron status was high. Young and nulliparous female garment workers in Cambodia might constitute a group with elevated risk for nutritional deficiencies. Strategies need to be developed for improving their nutritional, micronutrient and health status. The poor iron status seems to contribute to the overall prevalence of anemia. Low hemoglobin and iron deficiency affected both underweight and those not underweight. Despite the fact that body mass index was negatively associated with iron stores, true differences in iron status between underweight and not underweight participants cannot be confirmed.
OBJECTIVE Parents with cancer are concerned about the impact of their disease on their children. However, parenting concerns and associated factors in cancer survivors have not previously been analyzed. The purpose of this study is to examine parenting concerns and to test a path model for understanding parenting concerns in cancer survivors. METHODS In a cross-sectional study, a total of 1416 parents with cancer (mean age 47.5years, 74% women) having minor or young-adult children were recruited through two cancer registries. Parenting concerns were assessed using the Parenting Concerns Questionnaire. Structural equation modeling (SEM) was used to analyze the associations between social support, parenting confidence, emotional distress, family functioning and parenting concerns. RESULTS Mothers reported higher total parenting concerns than fathers (p<0.001). We observed strong effects of emotional distress and parenting confidence on parenting concerns. Family dysfunctioning was associated with lower concerns. An indirect association between social support and parenting concerns was identified. CONCLUSION Parenting concerns in cancer survivors display the need for interventions and after care programs that focus on affected families with minor and young adult children. The results of the structural path model illustrate the associations between psychological and interactional factors. Supporting parents with cancer in their parenting confidence and strengthen social support and family functioning may not only reduce the long-term burden on the parents themselves but also the burden on the entire family.
OBJECTIVE Although cancer patients with minor children have become more of a focus of psycho-oncological research, little is known about specific parenting concerns. Instruments to assess the concerns and worries of parents with cancer are rare. The Parenting Concerns Questionnaire (PCQ) addresses this issue. We analyzed parenting concerns in cancer survivors and evaluated the German version of the PCQ. METHODS A total of 1416 cancer survivors with minor and young adult children (≤21 years) were recruited in a register-based study. Descriptive analyses as well as reliability and validity analyses were conducted. We performed a confirmatory factorial analysis of the factor structure proposed by the authors of the original version on the PCQ. RESULTS Seventy-three percent of the cancer survivors were women, average age was 47.5 years (SD 5.9). Mean time since diagnosis was 44 months (SD 23.4). Between 18 and 31% of survivors reported that they were concerned about their children. The PCQ proved to be a reliable and valid instrument showing medium correlations with standardized measures in expected directions and discriminating between survivors with and without use of psychosocial support services. The factor structure was supported by the confirmatory factorial analysis. CONCLUSIONS Assessing parenting concerns gives an additional insight into the situation of parents with cancer. In our sample of cancer survivors, we identified one out of three survivors being concerned regarding the impact of their illness on their children. The PCQ can be considered as a valid and reliable instrument with regard to identifying concerned parents with cancer. Copyright © 2015 John Wiley & Sons, Ltd.
n this work the synthesis of a linear hexapeptide with a hydroxylamine functionality at the N‐terminus and a ketone instead of the carboxylic acid at the C‐terminus is described. Cyclization by ketoxime formation yields the 19‐membered ring‐expanded cyclic hexapeptide cyclo[Goly‐Val‐Ala‐Pro‐Leu‐Kly] which adopts a main conformer with two intramolecular hydrogen bonds. The hydrolytic stability of a ketoxime lies between the inert amide and the labile imine. The substitution of an amide bond for an iminium bond transforms the irreversible macrocyclization into a reversible process, but macrocyclic imines are difficult to isolate because they are prone to hydrolysis. The enhanced chemical stability of the ketoxime justifies its application in ligation protocols. The detailed NMR analysis of a ketoxime linkage presented here identifies its local conformational preferences in a constrained peptide environment.
People adapt their word choice to both humans and computers. In this study, language style (elaborated vs. restricted) and perceived conversational partner (human vs. spoken dialogue system) were varied. Convergence was greater when reacting to a restricted language style. Participants preferred human partners and an elaborated language style. In line with communication accommodation theory, results suggest that considering restricted capabilities (cognitive organization) constitutes a central motive for convergence. Implications for spoken dialogue system design are discussed.
Power: the missing element in sustainable consumption and absolute reductions research and action
(2016)
In this essay, we aim to demonstrate the value of a power lens on consumption and absolute reductions. Specifically, we illuminate what we perceive to be a troublesome pattern of neglect of questions of power in research and action on sustainable consumption and absolute reductions. In pursuit of our objectives, we delineate how many of the informal and implicit “theories of social change” of scholars and activists in sustainable consumption and sustainable development fail to address power in a sufficiently explicit, comprehensive and differentiated manner and how that failure translates into insufficient understandings of the drivers of consumption and the potential for and barriers to absolute reductions. Second, we develop the contours of a power lens on sustainable consumption. Third, we illustrate the value of such a power lens, with a particular focus on the case of meat consumption.
Stormwater pollutant process analysis with long-term on-line monitoring data at micro scale sites
(2016)