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- keine Zuordnung (90) (remove)
In Kooperation mit namhaften Firmen und Institutionen sind im Absolventenjahrgang 2001 wertvolle Diplomarbeiten entstanden, deren Ergebnisse in die dortigen Abläufe nutzbringend integriert wurden. Das zeugt von der fachlichen Kompetenz der Diplomanden. Die hier prämierten "Top Ten" zeichnen sich in besonderer Weise durch ihren Praxis-, Wissenschafts- und Anwendungsbezug aus und werden deshalb bezug geehrt.
Unter den 1000 Abschlussarbeiten, die jedes Jahr ander Fachhochschule Münster angefertigt werden, gilt es die herausragendsten des Jahres 1999 zu ehren. Der besonders hohe Anspruch wird dabei durch den Praxis-, Wissenschafts- und Anwendungsbezug hergestellt. Elf Diplomandinnen und Diplomanden aus den Fachbereichen der Hochschule erfahren diese besondere Ehrung.
Background
While research on exercise interventions during anticancer treatment is well-established in adults, only very few studies exist in children. However, pediatric patients experience great limitations to being physically active, and appropriate interventions are desired.
Procedure
The present study aimed at investigating the effects of individualized exercise interventions during inpatient stays on pediatric patients with a malignant bone tumor. The parameter of interest was physical activity (PA). Patients’ PA during home stays was assessed 6 weeks as well as 3, 6, 12, and 18 months post-surgery. Patients were distinguished into an intervention group and a control group. All patients received endoprosthetic replacement of the affected bone in the same institution.
Results
A constant increase in all PA parameters was observed during follow-up. Exercise interventions were possible and appeared worthwhile. The intervention group showed better PA results at all measurements; however, no significant differences between groups were found. Furthermore, differences decreased especially after the cessation of the intervention. General problems in reaching appropriate power and compliance were observed.
Conclusions
Individualized exercise interventions in pediatric bone tumor patients are possible and appear to be beneficial. Such interventions should be implemented in adjuvant care; however, future research is needed to understand more about the effects of different interventions.
A new measurement system (horizontal displacement, time of flight, synchronicity—HDTS) was investigated regarding the latest changes to the international evaluation rules in trampoline gymnastics. It allows for the real-time measurement of objective criteria, such as flight time and landing position, without affecting the gymnast. The aim of this study was to investigate the temporal and spatial accuracy of a measurement tool via cross-validation. Temporal precision was additionally tested via high-speed video landing and takeoff, while a three-dimensional motion capturing system was incorporated for spatial precision. The Bland–Altman “limit of agreement approach” was used for the assessment of congruence between the measurement systems. The new measurement system presented an average spatial deviation of 3.2 cm and a temporal deviation between − 5.8 and + 6.4 ms for the landing and − 11.3 and + 11.3 ms for the takeoff. Given its temporal and spatial accuracy in determining flight time and landing position as identified through cross-validation, the novel HDTS system proved to be suitable for its use in trampoline competitions.
Despite growing interest in light-driven ion pumps for use in optogenetics, current estimates of their transport rates span two orders of magnitude due to challenges in measuring slow transport processes and determining protein concentration and/or orientation in membranes in vitro. In this study, we report, to our knowledge, the first direct quantitative measurement of light-driven Cl− transport rates of the anion pump halorohodopsin from Natronomonas pharaonis (NpHR). We used light-interfaced voltage clamp measurements on NpHR-expressing oocytes to obtain a transport rate of 219 (± 98) Cl−/protein/s for a photon flux of 630 photons/protein/s. The measurement is consistent with the literature-reported quantum efficiency of ∼30% for NpHR, i.e., 0.3 isomerizations per photon absorbed. To reconcile our measurements with an earlier-reported 20 ms rate-limiting step, or 35 turnovers/protein/s, we conducted, to our knowledge, novel consecutive single-turnover flash experiments that demonstrate that under continuous illumination, NpHR bypasses this step in the photocycle.