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- physical activity (5)
- childhood cancer (3)
- Aktivitätserfassung (2)
- Malignant bone tumor (2)
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- Adoleszenz (1)
- Akzelerometer (1)
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This review provides a survey of studies investigating physical activity and exercise interventions in patients during tumor treatment and survivors of childhood cancer. PubMed and Medline databases were searched using relevant terms. References of selected papers were tracked. A total of 28 studies could be identified. Seventeen studies investigated physical activity, 11 studies determined the effect of activity enhancing interventions during and after therapy. Even though most studies showed limitations and results were not consistent, considerably reduced physical activity is highly probable in patients during and after therapy. Studies on interventions provided promising results and revealed challenges to be faced. Pediatr Blood Cancer
Purpose
The diagnosis of a malignant bone tumor in the lower limb is a risk factor for physical disability, limiting physical performance. Walking ability especially, which is essential for most activities of daily living, is limited in those patients. In the present study, the extent of limitations during the course of treatment was investigated to determine when the assessment of functional parameters is meaningful in those patients.
Methods
In the present study, activity levels were determined in 20 patients with a malignant bone tumor in the lower limb who received endoprosthetic replacement of the affected bone and in 20 healthy individuals. A uniaxial accelerometer was used to investigate patients at five different time points after surgery.
Results
Patients performed significantly less amounts and intensities of activity than control individuals at all measurements. Significant increases in the volume of activity were observed after cessation of treatment. However, the intensity of activity only showed minor increases. Patients experiencing complications of surgery revealed greater restriction than those without even 18 months after surgery.
Conclusions
After cessation of treatment for their disease, patients recovered markedly and showed great improvements in physical activity. However, some limitations appeared to persist. Comparisons with patients with longer follow-up revealed that meaningful functional assessment does not make sense within the first 12 months after surgery. More research is needed to show if longer follow-up periods reveal further improvements. Based on such information, it should be more promising to develop individually tailored activity recommendations and intervention programs.
Background
The diagnosis of cancer bears severe implications for pediatric patients. One immense restriction consists in a reduced level of activity due to different factors. Physical activity affects various aspects of development and can be regarded as an essential part of a child's life. In the present study physical activity in patients undergoing cancer therapy was quantified in order to determine the extent of the restriction and to provide baseline information for the assessment of possible interventions.
Procedure
Physical activity in 80 patients and 45 healthy children matched for age and gender was measured using the StepWatch 3™ Activity Monitor (SAM, OrthoCare Innovations).
Results
Pediatric cancer patients, at 2,787 gait cycles (gcs) per day, were significantly less active than their healthy counterparts (8,096 gcs). Patients were significantly more active at home than during inpatient stays (3,185 gcs compared to 1,830 gcs), and patients with bone tumors were less active than those with leukemia regarding both, the amount (1,849 gcs vs. 2,992 gcs) and the intensity of activity.
Conclusion
The present study quantified an often observed but so far hardly assessable problem. Activity in cancer patients is considerably reduced and patients with bone tumors are at increased risk from the detrimental effects of prolonged inactivity. Both our findings and the accepted fact that activity is an essential element of child development confirm the need for interventions tailored to a patient's needs and abilities during the course of treatment.
Tumorerkrankungen im Kindes- und Jugendalter haben während der Akuttherapie und darüber hinaus einen signifikanten Einfluss auf das Aktivitätsniveau und den Knochenstoffwechsel. Dieser Beitrag untersucht, inwiefern bewegungstherapeutische Interventionen das Aktivitätsniveau und damit auch die Entwicklung der Knochendichte während der Akuttherapie von Patienten mit Knochentumoren der unteren Extremität beeinflussen können. 21 Kinder und Jugendliche im Alter von 13,6 Jahren konnten in die Untersuchung aufgenommen werden und wurden einer Interventions- (IG, n=10) oder einer Kontrollgruppe (KG, n=11) zugeordnet. Sämtliche Patienten erhielten die standardisierte physiotherapeutische Behandlung. Der IG wurde zusätzlich ein Sportprogramm angeboten, das an jedem zweiten Tag während der Akuttherapie absolviert werden sollte. Die Knochendichte der Lendenwirbelsäule und des nicht betroffenen Schenkelhalses wurde mittels Dual-Röntgen-Absorptiometrie (DXA) während der Lokaltherapie, sowie nach sechs und nach zwölf Monaten erfasst. Die Alltagsaktivitäten wurden zeitgleich nach sechs und zwölf Monaten im heimischen Umfeld objektiv mit einem Beschleunigungsaufnehmer über einen Zeitraum von sieben Tage erhoben. In beiden Patientengruppen wurde während der Akuttherapie eine deutliche Reduktion der Knochendichte beobachtet. Im Gruppenvergleich zeigten sich in der Entwicklung der Knochendichte zwischen den Messzeitpunkten kleine bis große Effekte zugunsten der bewegungstherapeutischen Intervention. Zudem weist die Interventionsgruppe im Vergleich zur Kontrollgruppe durchweg signifikant höhere Alltagsaktivitäten (durchschnittliche Schrittzahl pro Tag und Phasen hoher körperlicher Aktivität) auf. Die Ergebnisse belegen die Durchführbarkeit und den Nutzen eines therapiebegleitenden Sportprogramms für Kinder und Jugendliche während der Akutphase der Behandlung einer Knochentumorerkrankung der unteren Extremität.
Die Erfassung von Alltagsaktivitäten (activities of daily life, ADL) ist unerlässlich, wenn der Zusammenhang von körperlicher Aktivität und Gesundheit aufgezeigt oder die Effizienz von Interventionen zur Steigerung der körperlichen Aktivität evaluiert werden soll. Derzeit existiert keine Methode, die präzise alle Formen der Alltagsaktivitäten erfassen kann. Diese Übersichtsarbeit beschreibt und vergleicht auf Basis einer umfassenden Literaturrecherche moderne Messverfahren zur Erfassung körperlicher Aktivitäten im Alltag, bei der die Darstellung objektiver Verfahren einen Schwerpunkt bildet.
Subjektive Erhebungsmethoden wie Fragebögen und objektive Aktivitätsmonitore, zu denen Schrittzähler und Akzelerometer zählen, sowie kombinierte Verfahren von Akzelerometrie und Herzfrequenz, sind derzeit die gängigsten Methoden, Alltagsaktivitäten zu erfassen. Daneben existieren weitere Möglichkeiten wie Doubly Labeled Water, Kalorimetrie oder direkte Beobachtungen der Testperson, die als Goldstandard des Activity Assessments angesehen und zur Validierung oben genannter Verfahren genutzt werden können. Obwohl diese Methoden das größte Potential bei der Erfassung körperlicher Aktivitäten hinsichtlich der Messpräzision haben, muss bei der Auswahl der Erhebungsmethode angesichts der Vielzahl an Möglichkeiten auch ihre Anwendbarkeit berücksichtigt werden. Die technischen Entwicklungen insbesondere im Bereich des Aktivitätsmonitorings machen eine ständige Auseinandersetzung mit seinen vielfältigen Möglichkeiten unerlässlich. Diese Übersicht soll für den Anwender eine Hilfestellung bei der Studienkonzipierung darstellen.
Zur Bestimmung der Messgenauigkeit handelsüblicher Bewegungssensoren wurden ein Akzelerometer und acht Pedometer von Schulkindern und jungen Erwachsenen unter kontrollierten Bedingungen und unter Alltagsbedingungen im Rahmen einer 24-stündigen Aktivitätsmessung getragen. Die präzisesten Ergebnisse unter kontrollierten Bedingungen wurden mit einem piezoelektrischen Pedometer erzielt. Die absoluten Abweichungen (Median) lagen für diesen Schrittzähler bei den Kindern zwischen 0,2 und 1,0%, bei den Erwachsenen zwischen 0,2 und 1,4%. Die absoluten Abweichungen für den Akzelerometer lagen zwischen 0,8 und 3,1% für die Schulkinder sowie zwischen 0,6 und 3,2% für die Erwachsenen. Die Messpräzision stieg unter kontrollierten Bedingungen mit zunehmender Bewegungsgeschwindigkeit an. Besonders bei den Schulkindern wiesen einige Schrittzähler mit Pendelarm-Mechanismus hohe absolute Abweichungen von über 50% auf. Die Unterschiede unter Alltagsbedingungen verdeutlichen, dass Schrittzahlangaben diverser Monitore nicht direkt miteinander verglichen werden können. In jedem Fall sollten Schrittzähler vor ihrem Einsatz in wissenschaftlichen Untersuchungen auf Gütekriterien wie Validität und Reliabilität gestestet werden.
Objective assessment of brace wear times and physical activities in two patients with scoliosis
(2010)
Conservative treatment of adolescent idiopathic scoliosis consists of therapeutic exercise and the application of braces. The effectiveness of bracing mainly depends on patient compliance, which can be determined by means of temperature sensors. This methodological paper describes the feasibility of objectively determining compliance and daily physical activities before and during conservative scoliosis treatment, being a relevant indicator for quality of life in children and adolescents. One patient with low compliance (61.4±24.9%) reduced her activity level during bracing by 50.1%, whereas another patient with a satisfactory compliance (85.7±19.5%) increased her daily activity level by 33.7% during conservative treatment.
The aim was to evaluate the effects of additional exercises during inpatient stays on bone mass in pediatric bone tumor patients. 21 patients were non-randomly allocated either to the exercise group (n=10) or the control group (n=11). DXA of the lumbar spine, the non-affected femur and both calcanei was performed after completion of neoadjuvant chemotherapy (baseline), as well as 6 and 12 months after baseline. Bone mineral content (BMC), bone mineral density (BMD) and height-corrected lumbar spine Z-scores were determined. Group changes after 6 and 12 months were compared by covariance analyses. Additionally, daily physical activities (PA) were assessed by means of accelerometry. After adjusting for initial age, height and weight, mean reductions in lumbar spine and femoral BMC were lower in the exercise group (not significant). Effect sizes during the observational period for lumbar spine and femur BMC were generally small (partial η²=0.03). The exercise group demonstrated substantially higher PA levels in terms of gait cycles per day, per hour and moderate PA (activities above 40 gait cycles per minute). Additional exercises for bone tumor patients are feasible during hospitalization. Though the intervention did not influence BMC, it appeared beneficial regarding PA promotion with respect to volume and intensity.
Objective
The aim of the study was to investigate the effects of a 4-wk inpatient rehabilitation program on postural control and gait in pediatric patients with cancer.
Design
Eighty-eight patients with brain tumors (n = 59) and bone/soft tissue sarcomas (n = 29) were evaluated. Postural control was assessed examining the velocity of the center of pressure and single-leg stance time on a pressure distribution platform. Walk ratio, a measure of neuromotor control, was used to evaluate intervention effects on gait.
Results
Repeated measures analysis of variance showed improvements in postural control measures, indicated by a decrease in velocity of center of pressure of −0.4 cm/sec (F1,80 = 7.175, P = 0.009, ηp2 = 0.082) and increase in single-leg stance time (mean [median] = 1.1 [2.6] sec, respectively; F1,80 = 12.617, P = 0.001, ηp2 = 0.136). Walk ratio increased by 0.2 mm/steps per min (F1,82 = 3.766, P = 0.056, ηp2 = 0.044). Mean changes in dependent variables did not differ between both patient groups (P > 0.05).
Conclusions
The results indicate benefits of an inpatient rehabilitation program comprising standard physical therapy as well as aquatic and hippo therapy on postural control and gait after treatment of pediatric patients with cancer.
Abstract
Purpose
Chronic health conditions and impaired quality of life are commonly experienced in childhood cancer survivors. While rehabilitation clinics support patients in coping with the disease, studies evaluating an inpatient rehabilitation program on promoting physical activity (PA) and health-related quality of life (HRQoL) are missing.
Methods
A 4-week inpatient rehabilitation program was prospectively evaluated. One hundred fifty patients with leukemia or lymphoma (N = 86), brain tumors (N = 38), and sarcomas (N = 26) were enrolled on average 17 months after cessation of acute medical treatment. PA amount and cadence (indicating the intensity of walking activity) using the StepWatch™ 3 Activity Monitor and HRQoL global and physical well-being scores using the KINDL® questionnaire were assessed before, immediately after, and 6 and 12 months following the program and analyzed using multiple linear mixed models.
Results
Significant effects on PA were only found at 12-month follow-up for amount and cadence variables (all p < 0.05). While leukemia and lymphoma patients revealed the highest PA level throughout the study, rehabilitation effects were more pronounced for cadence variables in brain tumor and sarcoma patients. The rehabilitation program had immediate (t = 4.56, p < 0.001) and sustainable effects on HRQoL global scores (6-month follow-up, t = 4.08, p < 0.001; 12-month follow-up, t = 3.13, p < 0.006).
Conclusions
Immediate and sustainable increases in HRQoL indicate that a 4-week rehabilitation program is beneficial for improving psychosocial well-being, while the significant increase in PA levels could be related to general recovery as well. The lack of a control group hampers the evaluation of the rehabilitation program on promoting PA levels in pediatric cancer patients.