TY - JOUR A1 - Meer, Nike A1 - Fischer, Tobias T1 - Medium-Chain Triglycerides (MCTs) for the Symptomatic Treatment of Dementia-Related Diseases: A Systematic Review JF - Journal of Nutrition and Metabolism Y1 - 2024 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:836-opus-179038 VL - 2024 SP - 1 EP - 17 ER - TY - JOUR A1 - Husain, Sarah A1 - Hillmann, Katharina A1 - Hengst, Karin A1 - Englert, Heike T1 - Effects of a lifestyle intervention on the biomarkers of oxidative stress in non-communicable diseases: A systematic review JF - Frontiers in Aging N2 - Oxidative stress plays a critical role in the pathogenesis of chronic diseases. Therefore, improvement of oxidative stress status through lifestyle intervention can play a vital role in preventing and treating chronic diseases. This systematic review aims to provide an overview of articles published in the last decade examining the association between lifestyle intervention and oxidative stress biomarkers in the context of non-communicable diseases. The electronic databases PubMed and Web of Science were searched for relevant studies, following the PRISMA (Preferred Reporting of Systematic Reviews and Meta-Analyses) guidelines. This systematic review focused on the four important oxidative stress biomarkers; glutathione (GSH), superoxide dismutase (SOD), catalase, and malondialdehyde. 671 articles were identified, of which nine met the inclusion criteria. A trend emerged, showing that lifestyle modifications that focus on diet and physical health can improve oxidative stress in the form of an increase in superoxide dismutase and CAT levels and a decrease in Malondialdehyde levels in participants with non-communicable diseases (NCDs), GSH levels were not affected. However, the results are difficult to compare because of the heterogeneity of the methods of the biomarkers studied. Our review indicates that oxidative stress can be influenced by lifestyle modifications and may be an effective tool for the prevention and management of non-communicable diseases. This review also elucidated the importance of analyzing multiple oxidative stress biomarkers to evaluate oxidative stress, it further highlights the need to conduct long-term lifestyle intervention studies on oxidative stress biomarkers to understand the connection between oxidative stress biomarkers, NCDs and Lifestyle intervention. KW - oxidative stress, lifestyle intervention, lifestyle diseases, antioxidants, non-communicable diseases, prevention, ageing, immunity Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:836-opus-160827 PB - Frontiers Journal CY - Germany ER - TY - JOUR A1 - Kranz, Ragna-Marie A1 - Kettler, Carmen A1 - Anand, Corinna A1 - Koeder, Christian A1 - Husain, Sarah A1 - Schoch, Nora A1 - Buyken, Anette A1 - Englert, Heike T1 - Effect of a controlled lifestyle intervention on medication use and costs: The Healthy Lifestyle Community Program (cohort 2) JF - Nutrition and Health N2 - Background: Establishing a healthy lifestyle has a great potential to reduce the prevalence of non-communicable diseases (NCDs) and their risk factors. NCDs contribute immensely to the economic costs of the health care system arising from therapy, medication use, and productivity loss. Aim: The aim of this study was to evaluate the effect of the Healthy Lifestyle Community Program (cohort 2; HLCP-2) on medication use and consequently on medication costs for selected NCDs (diabetes, hypertension, and dyslipidemia). Methods: Data stem from a 24-month non-randomised, controlled intervention trial aiming to improve risk factors for NCDs. Participants completed questionnaires at six measurement time points assessing medication use, from which costs were calculated. The following medication groups were included in the analysis as NCD medication: glucose-lowering medications (GLM), antihypertensive drugs (AHD) and lipid-lowering drugs (LLD). Statistical tests for inter- and intra-group comparison and multiple regression analysis were performed. Results: In total, 118 participants (intervention group [IG]: n = 79; control group [CG]: n = 39) were considered. Compared to baseline medication use decreased slightly in the IG and increased in the CG. Costs for NCD medication were significantly lower in the IG than in the CG after 6 (p = 0.004), 12 (p = 0.040), 18 (p = 0.003) and 24 months (p = 0.008). After multiple regression analysis and adjusting for confounders, change of costs differed significantly between the groups in all final models. Conclusion: The HLCP-2 was able to moderately prevent an increase of medication use and thus reduce costs for medication to treat NCDs with the greatest impact on AHD. Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:836-opus-162176 SN - 2047-945X PB - Sage Publications ER - TY - JOUR A1 - Heidt, C. A1 - Fobker, M. A1 - Newport, M. A1 - Feldmann, R. A1 - Fischer, T. A1 - Marquardt, T. T1 - Beta-Hydroxybutyrate (BHB), Glucose, Insulin, Octanoate (C8), and Decanoate (C10) Responses to a Medium-Chain Triglyceride (MCT) Oil with and without Glucose: A Single-Center Study in Healthy Adults JF - Nutrients Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:836-opus-170851 VL - 15 IS - 5 SP - 1 EP - 17 ER - TY - JOUR A1 - Kranz, Ragna-Marie A1 - Kettler, Carmen A1 - Koeder, Christian A1 - Husain, Sarah A1 - Anand, Corinna A1 - Schoch, Nora A1 - Englert, Heike T1 - Health Economic Evaluation of a Controlled Lifestyle Intervention: The Healthy Lifestyle Community Program (Cohort 2; HLCP-2) JF - Nutrients N2 - Non-communicable diseases (NCD) are associated with high costs for healthcare systems. We evaluated changes in total costs, comprising direct and indirect costs, due to a 24-month non-randomized, controlled lifestyle intervention trial with six measurement time points aiming to improve the risk profile for NCDs. Overall, 187 individuals from the general population aged ≥18 years were assigned to either the intervention group (IG; n = 112), receiving a 10-week intensive lifestyle intervention focusing on a healthy, plant-based diet; physical activity; stress management; and community support, followed by a 22-month follow-up phase including monthly seminars, or a control group (CG; n = 75) without intervention. The complete data sets of 118 participants (IG: n = 79; CG: n = 39) were analyzed. At baseline, total costs per person amounted to 67.80 ± 69.17 EUR in the IG and 48.73 ± 54.41 EUR in the CG per week. The reduction in total costs was significantly greater in the IG compared to the CG after 10 weeks (p = 0.012) and 6 months (p = 0.004), whereas direct costs differed significantly after 10 weeks (p = 0.017), 6 months (p = 0.041) and 12 months (p = 0.012) between the groups. The HLCP-2 was able to reduce health-related economic costs, primarily due to the reduction in direct costs. Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:836-opus-174544 ER - TY - JOUR A1 - Clever, Lena A1 - Schatto-Eckrodt, Tim A1 - Clever, Nico A1 - Frischlich, Lena T1 - Behind Blue Skies: A Multimodal Automated Content Analysis of Islamic Extremist Propaganda on Instagram JF - Social Media + Society KW - natural language processing KW - automated content analysis KW - collective action KW - deep learning KW - Islamic extremism Y1 - 2023 U6 - http://dx.doi.org/10.25974/fhms-17946 VL - 9 IS - 1 ER - TY - JOUR A1 - Wos, Karolina A1 - Borghoff, Lisa Marie A1 - Horvat, Andrijana A1 - Paoletti, Flavio A1 - Saggia Civitelli, Eleonora A1 - Rembiałkowska, Ewa ED - Bacenetti, Jacopo T1 - Preliminary Analysis of Voluntary Information on Organic Milk Labels in Four European Union Countries JF - Sustainability N2 - The concern for the environment among European consumers is growing and in the future the need for sustainable shopping is expected to increase. Through transparent on-packaging communication with consumers, organic producers have the opportunity to show attributes of organic production system and build a strong market position. The aim of the study was to analyse voluntary packaging information on organic milk from four European markets in the context of organic food quality, i.e., Germany, the Netherlands, Italy and Poland. More specifically, the textual content of 106 organic milk packages was analysed and voluntary information on each package was categorized according to process- and product-related organic milk attributes. The assortment and content of voluntary packaging information varied across the four countries. The largest number of products was found on the German market (37) and the smallest on the Polish market (14). Dutch milk had the greatest amount of voluntary information on animal welfare, product locality, environmental protection, quality confirmation, naturalness and nutritional value. German milk had the most information on enjoyment and conditions of processing, while the Italian milk on the social perspective. The products available on the Polish market had the least voluntary information. Pasteurized organic milk had noticeably more information about organic quality attributes than micro filtrated and UHT milk. KW - milk package KW - organic KW - content analysis KW - optional KW - value Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:836-opus-156981 SP - 1 EP - 18 PB - MDPI ER - TY - CHAP A1 - Koeder, Christian A1 - Hahn, Andreas A1 - Englert, Heike T1 - A plant-based diet and healthy lifestyle lower C-reactive protein levels T2 - Complement Med Res N2 - Introduction: Many disease processes are accompanied and promoted by increased inflammation in the body. Increased concentrations of high-sensitivity C-reactive protein (hs-CRP) in the blood are an indicator of subclinical inflammation, increased disease risk, and an increased risk of early death. A healthy plant-based diet and increased physical activity have been shown to reduce hs-CRP concentrations. Objectives: Our objective was to test if a healthy lifestyle intervention program can improve hs-CRP levels and other risk factors. Methodology: We are conducting a non-randomized, controlled intervention study with 6 times of measurement (baseline, after 2.5, 6, 12, 18 and 24 months). Participants in the intervention group (n = 104) took part in a 2.5-month intensive lifestyle program focusing on a plant-based diet (PBD), physical activity, stress management and group support. Currently they are in the less intensive phase (monthly seminars) which will be completed after 24 months. The control group (n = 62) did not take part in any program. In both groups hs-CRP was assessed, and participants with an infection/common cold at any of the times of measurement were excluded from the analyses. Results: In the intervention group (n = 97) we observed a reduction in hsCRP from baseline to 2.5 months (p < 0.001). In the control group (n = 46) hs-CRP levels increased non-significantly. The changes from baseline to 2.5 months were significantly different between intervention and control (p < 0.01). Conclusion: Our program led to a clinically relevant reduction in hs-CRP. Continued follow-up will show if this improvement can be maintained in the intervention group. Our study confirms that a PBD and healthier lifestyle choices can lower hs-CRP. KW - plant-based diet KW - inflammation KW - cardiovascular disease KW - cancer Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:836-opus-131847 UR - https://pubmed.ncbi.nlm.nih.gov/33631741/ SP - 6 EP - 7 ER - TY - RPRT A1 - Röckinghausen, Simon A1 - Clever, Nico A1 - Köffer, Sebastian T1 - Coworking Spaces im Münsterland N2 - Coworking Spaces sind mittlerweile fester Bestandteil der digitalen Arbeitslandschaft in Großstädten. Nach und nach halten sie auch im ländlichen Raum Einzug. Studien und Modellprojekte haben bewiesen, dass sie sowohl gesellschaftlich als auch wirtschaftlich eine positive Wirkung auf strukturschwächere Regionen haben können. Sie bieten ein attraktives Umfeld für Kreative und Gründer und ermöglichen den Austausch mit lokalen Unternehmen. Außerdem können sie dafür sorgen, dass Pendler* innen zum Arbeiten vor Ort bleiben. In weniger dicht besiedelten Regionen, wie dem Münsterland, ist der profitable Betrieb von Coworking Spaces bisweilen schwierig. Da naturgemäß die Standortwahl eines Coworking Space ein entscheidendes Kriterium für seine spätere Wirtschaftlichkeit ist, wird diese in der vorliegenden Studie untersucht. Dazu werden auf Coworking Spaces zugeschnittene und von Experten gewichtete Standortfaktoren aufgestellt und die 65 Orte des Münsterlands anhand dieser Faktoren bewertet. So entsteht ein Ranking, welches aufzeigt, wo die besten Voraussetzungen für Coworking Spaces herrschen. In einigen Städten im Münsterland gibt es bereits Coworking Spaces. Einem Großteil dieser Orte wird durch diese Studie eine gute Eignung bestätigt. Beispielsweise schneiden Rheine und Bocholt aufgrund ihrer hohen Einwohnerzahl am besten ab. Es wird jedoch deutlich, dass auch andere Faktoren ausschlaggebend sein können. So bewerten Expert*innen die digitale Infrastruktur und Erreichbarkeit als sehr wichtig. Für diese Faktoren stellen vergleichsweise kleine Orte die Bestwerte, die bislang noch keine Coworking Spaces vorweisen können. Die Ergebnisse informieren Betreiber*innen von Coworking Spaces und solche, die es werden wollen, sowie politische Entscheidungsträger*innen über mögliche Potenziale in den jeweiligen Orten. Sie zeigen auf, an welchen Stellschrauben gedreht werden kann, um gute Voraussetzungen zu schaffen. Darüber hinaus wird empfohlen, das entstehende Angebot aufeinander abzustimmen und gemeinschaftlich vorzugehen – so, wie es der Begriff Coworking bereits verdeutlicht. KW - Coworking Space KW - Standortfaktoren KW - Münsterland Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:836-opus-133220 ER - TY - JOUR A1 - Baumeister, Anna A1 - Gardemann, Joachim A1 - Fobker, Manfred A1 - Spiegler, Verena A1 - Fischer, Tobias T1 - Short-Term Influence of Caffeine and Medium-Chain Triglycerides on Ketogenesis: A Controlled Double-Blind Intervention Study JF - Hindawi Journal of Nutrition and Metabolism N2 - Background. Ketone bodies are a highly relevant topic in nutrition and medicine. -e influence of medium-chain triglycerides (MCT) on ketogenesis is well known and has been successfully used in ketogenic diets for many years. Nevertheless, the effects of MCTs and coconut oil on the production of ketone bodies have only partially been investigated. Furthermore, the increased mobilisation of free fatty acids and release of catabolic hormones by caffeine suggest an influence of caffeine on ketogenesis. Methods. In a controlled, double-blind intervention study, seven young healthy subjects received 10mL of tricaprylin (C8), tricaprin (C10), C8/C10 (50% C8, 50% C10), or coconut oil with or without 150 mg of caffeine, in 250mL of decaffeinated coffee, over ten interventions. At baseline and after every 40 minutes, for 4 h, ßHB and glucose in capillary blood as well as caffeine in saliva were measured. Furthermore, questionnaires were used to survey sensory properties, side effects, and awareness of hunger and satiety. Results. -e interventions with caffeine caused an increase in ßHB levels—in particular, the interventions with C8 highly impacted ketogenesis. -e effect decreased with increased chain lengths. All interventions showed a continuous increase in hunger and diminishing satiety. Mild side effects (total � 12) occurred during the interventions. Conclusions. -e present study demonstrated an influence of caffeine and MCTon ketogenesis. -eaddition of caffeine showed an additive effect on the ketogenic potential of MCT and coconut oil. C8 showed the highest ketogenicity. KW - Ketogenesis KW - Caffeine Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:836-opus-138069 VL - Volume 2021, Article ID 1861567 SP - 1 EP - 9 ER -