TY - GEN A1 - Knehans, Oliver A1 - Schupp, Thomas A1 - Wäsche, Andreas T1 - Lignin und andere Extraktstoffe aus Laubblättern (Organosolv-Verfahren). Beitrag zum Workshop: Energie und Wertstoffe aus biogenen Reststoffen. Fraunhofer Umsicht am 01. Dezember 2015 in Oberhausen Y1 - 2015 ER - TY - JOUR A1 - Schupp, Thomas T1 - Modeling formation and distribution of toluene-2,4-diamine (TDA) after spillage of toluene-2,4-diisocyanate (TDI) into a river. JF - Journal of Hazardous Materials Y1 - 2013 VL - 252-253 SP - 70 EP - 76 ER - TY - JOUR A1 - Schupp, Thomas A1 - Michael, A T1 - Toluene diisocyanate (TDI) airway effects and dose-responses in different animal models. JF - EXCLI Journal Y1 - 2012 VL - 11 SP - 416 EP - 435 ER - TY - JOUR A1 - Schupp, Thomas A1 - Robert, J T1 - Primary aromatic amines: the contribution of sediment organisms to human exposure. JF - EXCLI Journal Y1 - 2007 VL - 6 SP - 187 EP - 196 ER - TY - JOUR A1 - Schupp, Thomas A1 - Hermann, M A1 - Bolt, Rudolph A1 - Jaeckh, Jan A1 - Hengstler, G T1 - Benzene and its methyl-derivatives: derivation of maximum exposure levels in automobiles. JF - Toxicology Letters Y1 - 2006 VL - 160 SP - 93 EP - 104 ER - TY - JOUR A1 - Schupp, Thomas A1 - Hermann, M A1 - Bolt, Jan A1 - Hengstler, G T1 - Maximum exposure levels for xylene, formaldehyde and acetaldehyde in cars. JF - Toxicology Y1 - 2005 VL - 206 IS - 3 SP - 461 EP - 470 ER - TY - JOUR A1 - Schupp, Thomas A1 - Jan, G T1 - A concept foer maximum exposure levels in cars. JF - EXCLI Journal Y1 - 2004 VL - 3 SP - 29 EP - 38 ER - TY - GEN A1 - Knehans, Oliver A1 - Schupp, Thomas A1 - Wäsche, Andreas T1 - Lignin und andere Extraktstoffe aus Laubblättern (Organosolv-Verfahren). Beitrag zum Workshop: Energie und Wertstoffe aus biogenen Reststoffen. Fraunhofer Umsicht am 01. Dezember 2015 in Oberhausen. Y1 - 2015 ER - TY - JOUR A1 - Gebel, Thomas A1 - Foth, Heidi A1 - Damm, Georg A1 - Freyberger, Alexius A1 - Kramer, Peter-Jürgen A1 - Lilienblum, Werner A1 - Röhl, Claudia A1 - Schupp, Thomas A1 - Weiss, Carsten A1 - Wollin, Klaus-Michael A1 - Georg, Jan T1 - Manufactured nanomaterials: categorization and approaches to hazard assessment JF - Arch Toxicol Y1 - 2014 U6 - http://dx.doi.org/10.1007/s00204-014-1383-7 VL - 88 SP - 2191 EP - 2211 ER - TY - JOUR A1 - Schupp, Thomas A1 - Austin, Tom A1 - Charles, V. A1 - Eadsforth, Bart A1 - Bossuyt, Summer A1 - Robert, J. T1 - A Review of the Environmental Degradation, Ecotoxicity, and Bioaccumulation Potential of the Low Molecular Weight Polyether Polyol Substances JF - Reviews of Environmental Contamionation and Toxicology Y1 - 2017 VL - 244 SP - 53 EP - 111 ER - TY - JOUR A1 - Schupp, Thomas T1 - Derivation of Indoor Air Guidance Values Volatile Organic Compounds (VOC) emitted from Polyurethane Flexible Foam: VOC with repeated dose toxicity data. JF - EXCLI Journal Y1 - 2018 U6 - http://dx.doi.org/http://dx.doi.org/10.17179/excli2018-1440 SN - 1611-2156 VL - 17 IS - 1116-2156 SP - 784 EP - 805 ER - TY - JOUR A1 - Schupp, Thomas T1 - READ ACROSS FOR THE DERIVATION OF INDOOR AIR GUIDANCE VALUES SUPPORTED BY PBTK MODELLING JF - EXCLI Journal Y1 - 2018 U6 - http://dx.doi.org/10.17179/excli2018-1734 VL - 17 SP - 1069 EP - 1078 ER - TY - JOUR A1 - Wollin, Klaus-Michael A1 - Damm, Georg A1 - Foth, Heidi A1 - Freyberger, Alexius A1 - Gebel, Thomas A1 - Mangerich, Aswin A1 - Gundert-Remy, Ursula A1 - Partosch, Falko A1 - Röhl, Claudia A1 - Schupp, Thomas A1 - Hengstler, Jan G. T1 - Critical evaluation of human health risks due to hydraulic fracturing in natural gas and petroleum production JF - Archives of Toxicology N2 - The use of hydraulic fracturing (HF) to extract oil and natural gas has increased, along with intensive discussions on the associated risks to human health. Three technical processes should be differentiated when evaluating human health risks, namely (1) drilling of the borehole, (2) hydraulic stimulation, and (3) gas or oil production. During the drilling phase, emissions such as NOx, NMVOCs (non-methane volatile organic compounds) as precursors for tropospheric ozone formation, and SOx have been shown to be higher compared to the subsequent phases. In relation to hydraulic stimulation, the toxicity of frac fluids is of relevance. More than 1100 compounds have been identified as components. A trend is to use fewer, less hazardous and more biodegradable substances; however, the use of hydrocarbons, such as kerosene and diesel, is still allowed in the USA. Methane in drinking water is of low toxicological relevance but may indicate inadequate integrity of the gas well. There is a great concern regarding the contamination of ground- and surface water during the production phase. Water that flows to the surface from oil and gas wells, so-called ‘produced water’, represents a mixture of flow-back, the injected frac fluid returning to the surface, and the reservoir water present in natural oil and gas deposits. Among numerous hazardous compounds, produced water may contain bromide, arsenic, strontium, mercury, barium, radioactive isotopes and organic compounds, particularly benzene, toluene, ethylbenzene and xylenes (BTEX). The sewage outflow, even from specialized treatment plants, may still contain critical concentrations of barium, strontium and arsenic. Evidence suggests that the quality of groundwater and surface water may be compromised by disposal of produced water. Particularly critical is the use of produced water for watering of agricultural areas, where persistent compounds may accumulate. Air contamination can occur as a result of several HF-associated activities. In addition to BTEX, 20 HF-associated air contaminants are group 1A or 1B carcinogens according to the IARC. In the U.S., oil and gas production (including conventional production) represents the second largest source of anthropogenic methane emissions. High-quality epidemiological studies are required, especially in light of recent observations of an association between childhood leukemia and multiple myeloma in the neighborhood of oil and gas production sites. In conclusion, (1) strong evidence supports the conclusion that frac fluids can lead to local environmental contamination; (2) while changes in the chemical composition of soil, water and air are likely to occur, the increased levels are still often below threshold values for safety; (3) point source pollution due to poor maintenance of wells and pipelines can be monitored and remedied; (4) risk assessment should be based on both hazard and exposure evaluation; (5) while the concentrations of frac fluid chemicals are low, some are known carcinogens; therefore, thorough, well-designed studies are needed to assess the risk to human health with high certainty; (6) HF can represent a health risk via long-lasting contamination of soil and water, when strict safety measures are not rigorously applied. KW - Hydraulic Fracturing, Fracing Y1 - 2020 U6 - http://dx.doi.org/10.1007/s00204-020-02758-7 VL - 94 SP - 967 EP - 1016 ER - TY - JOUR A1 - Schupp, Thomas A1 - Damm, Georg A1 - Foth, Heidi A1 - Freyberger, Alexius A1 - Gebel, Thomas A1 - Gundert-Remy, Ursula A1 - Hengstler, Jan G. A1 - Mangerich, Aswin A1 - Partosch, Falko A1 - Röhl, Claudia A1 - Wollin, Klaus-Michael T1 - Long‑term simulation of lead concentrations in agricultural soils in relation to human adverse health effects JF - Archives of Toxicology N2 - Lead (Pb) exposure of consumers and the environment has been reduced over the past decades. Despite all measures taken, immission of Pb onto agricultural soils still occurs, with fertilizer application, lead shot from hunting activities, and Pb from air deposition representing major sources. Little is known about the intermediate and long-term consequences of these emissions. To gain more insight, we established a mathematical model that considers input from fertilizer, ammunition, deposition from air, uptake of Pb by crops, and wash-out to simulate the resulting Pb concentrations in soil over extended periods. In a further step, human oral exposure by crop-based food was simulated and blood concentrations were derived to estimate the margin of exposure to Pb-induced toxic effects. Simulating current farming scenarios, a new equilibrium concentration of Pb in soil would be established after several centuries. Developmental neurotoxicity represents the most critical toxicological effect of Pb for humans. According to our model, a Pb concentration of ~ 5 mg/kg in agricultural soil leads to an intake of approximately 10 μg Pb per person per day by the consumption of agricultural products, the dose corresponding to the tolerable daily intake (TDI). Therefore, 5 mg Pb/kg represents a critical concentration in soil that should not be exceeded. Starting with a soil concentration of 0.1 mg/kg, the current control level for crop fields, our simulation predicts periods of ~ 50 and ~ 175 years for two Pb immission scenarios for mass of Pb per area and year [scenario 1: ~ 400 g Pb/(ha × a); scenario 2: ~ 175 g Pb/(ha × a)], until the critical concentration of ~ 5 mg/kg Pb in soil would be reached. The two scenarios, which differ in their Pb input via fertilizer, represent relatively high but not unrealistic Pb immissions. From these scenarios, we calculated that the annual deposition of Pb onto soil should remain below ~ 100 g/(ha × a) in order not to exceed the critical soil level of 5 mg/kg. We propose as efficient measures to reduce Pb input into agricultural soil to lower the Pb content of compost and to use alternatives to Pb ammunition for hunting. KW - Lead · Pb · Hunting · Gunshot · Fertilizer · Soil contamination · Food contamination · Consumer risk Y1 - 2020 U6 - http://dx.doi.org/https://doi.org/10.1007/s00204-020-02762-x VL - 94 / 2020 SP - 2319 EP - 2329 ER - TY - BOOK A1 - Schupp, Thomas T1 - Hazardous substances N2 - This title presents a detailed overview on the full range of hazard categories and the associated risks of chemicals. It provides a basic introduction into toxicology, ecotoxicology and environmental behavior and enables all who perform precise chemical analysis to handle substances according to their intrinsic properties such as physical-chemical, environmental, ecological and toxicological hazards. KW - Chemistry, Toxicology, Ecotoxicology Y1 - 2020 SN - 978-3-11-061805-1 PB - De Gruyter CY - Berlin ER - TY - JOUR A1 - Boeing, Christian A1 - Sandten, Christian A1 - Hrincius, Eike R. A1 - Anhlan, Darisuren A1 - Dworog, Andreas A1 - Hanning, Stephanie A1 - Kuennemann, Thilo A1 - Niehues, Christopher A1 - Schupp, Thomas A1 - Stec, Edyta A1 - Thume, Julius A1 - Triphaus, Daniel A1 - Wilkens, Markus A1 - Uphoff, Holger A1 - Zuendorf, Josef A1 - Jacobshagen, Anja A1 - Kreyenschmidt, Martin A1 - Ludwig, Stephan A1 - Mertins, Hans-Christoph A1 - Mellmann, Alexander T1 - Decontamination of disposable respirators for reuse in a pandemic employing in-situ-generated peracetic acid JF - AJIC: American Journal of Infection Control N2 - Background During shortages of filtering face pieces (FFP) in a pandemic, it is necessary to implement a method for safe reuse or extended use. Our aim was to develop a simple, inexpensive and ecological method for decontamination of disposable FFPs that preserves filtration efficiency and material integrity. KW - Decontamination KW - FFP KW - Hydrogen peroxide KW - Acetic Acid KW - COVID-19 Y1 - 2021 UR - https://www.ajicjournal.org/article/S0196-6553(21)00620-9/fulltext#seccesectitle0002 U6 - http://dx.doi.org/10.1016/j.ajic.2021.09.017 SN - 0196-6553 VL - 2021 IS - September 22 ER - TY - JOUR A1 - Sandten, Christian Stefan A1 - Böing, Christian A1 - Hrincius, Eike A1 - Anhlan, Darisuren A1 - Kreyenschmidt, Martin A1 - Ludwig, Stephan A1 - Mertins, Hans-Christoph A1 - Mellmann, Alexander A1 - Dworog, Andreas A1 - Hanning, Stephanie A1 - Kuennemann, Thilo A1 - Niehues, Christopher A1 - Schupp, Thomas A1 - Stec, Edyta A1 - Thume, Julius A1 - Triphaus, Daniel A1 - Wilkern, Markus A1 - Uphoff, Holger A1 - Zündorf, Josef A1 - Jacobshagen, Anja T1 - Decontamination of disposable respirators for reuse in a pandemic employing in-situ-generated peracetic acid JF - American Journal of Infection Control KW - Sars-CoV-2 Y1 - 2021 UR - https://www.ajicjournal.org/action/showPdf?pii=S0196-6553%2821%2900620-9 U6 - http://dx.doi.org/10.1016/j.ajic.2021.09.017 VL - 00 / 2021 SP - 1 EP - 7 ER -