TY - JOUR A1 - Koeder, Christian A1 - Kranz, Ragna-Marie A1 - Anand, Corinna A1 - Husain, Sarah A1 - Alzughayyar, Dima A1 - Schoch, Nora A1 - Hahn, Andreas A1 - Englert, Heike T1 - Effect of a 1-year controlled lifestyle intervention on body weight and other risk markers (the Healthy Lifestyle Community Programme, cohort 2) JF - Obesity Facts KW - Adipositas KW - Lebensstil KW - pflanzenbasierte Ernährung Y1 - 2021 U6 - http://dx.doi.org/10.1159/000521164 ER - TY - JOUR A1 - Koeder, Christian A1 - Anand, Corinna A1 - Husain, Sarah A1 - Kranz, Ragna-Marie A1 - Schoch, Nora A1 - Alzughayyar, Dima A1 - Bitterlich, Norman A1 - Hahn, Andreas A1 - Englert, Heike T1 - Exploratory analysis of the effect of a controlled lifestyle intervention on inflammatory markers – the Healthy Lifestyle Community Programme (cohort 2) JF - BMC Nutrition N2 - Background Chronic low-grade inflammation is associated with an increased risk of chronic disease and mortality. The objective of the study was to test the effect of a healthy lifestyle intervention on biomarkers of inflammation (among other risk markers). Methods We conducted a non-randomized controlled trial with mostly middle-aged and elderly participants from the general population in rural northwest Germany (intervention: n = 114; control: n = 87). The intervention consisted of a 1-year lifestyle programme focusing on diet (largely plant-based; strongest emphasis), physical activity, stress management, and social support. High-sensitivity C-reactive protein (hs-CRP) was assessed at baseline, 10 weeks, 6 months, and 1 year. Homocysteine (Hcy) was assessed at baseline, 10 weeks, and 1 year. Adiponectin (Apn) was assessed at baseline and 10 weeks. An exploratory analysis of these inflammatory markers assessing the between-group differences with ANCOVA was conducted. Results The 1-year trajectory of hs-CRP was significantly lower in the intervention group compared to control (between-group difference: -0.8 (95% CI -1.2, -0.3) mg/l; p = 0.001; adjusted for baseline). The 1-year trajectory of Hcy was non-significantly higher in the intervention compared to control (between-group difference: 0.2 (95% CI -0.3, 0.7) µmol/l; p = 0.439; adjusted for baseline). From baseline to 10 weeks, Apn decreased significantly more in the intervention group compared to control (between-group difference: -1.6 (95% CI -2.7, -0.5) µg/ml; p = 0.004; adjusted for baseline). Conclusions Our study shows that healthy lifestyle changes can lower hs-CRP and Apn levels and are unlikely to significantly affect Hcy levels within 1 year. Trial registration German Clinical Trials Register (DRKS; reference: DRKS00018775, registered 12 Sept 2019; retrospectively registered; www.drks.de). Y1 - 2023 U6 - http://dx.doi.org/10.1186/s40795-023-00684-2 SN - 2055-0928 VL - 9 IS - 25 ER - TY - JOUR A1 - Koeder, Christian A1 - Alzughayyar, Dima A1 - Anand, Corinna A1 - Kranz, Ragna-Marie A1 - Husain, Sarah A1 - Schoch, Nora A1 - Hahn, Andreas A1 - Englert, Heike T1 - The healthful plant-based diet index as a tool for obesity prevention – the Healthy Lifestyle Community Program cohort 3 study JF - Obesity Science and Practice N2 - Background Worldwide the prevalence of obesity is high, and promoting a shift towards more healthful and more plant-based dietary patterns appears to be one promising strategy to address this issue. A dietary score to assess adherence to a healthy plant-based diet is the healthful plant-based diet index. While there is evidence from cohort studies that an increased healthful plant-based diet index is associated with improved risk markers, evidence from intervention studies is still lacking. Methods A lifestyle intervention was conducted with mostly middle-aged and elderly participants from the general population (n = 115). The intervention consisted of a 16-month lifestyle program focusing on a healthy plant-based diet, physical activity, stress management, and community support. Results After 10 weeks, significant improvements were seen in dietary quality, body weight, body mass index, waist circumference, total cholesterol, measured and calculated LDL cholesterol, oxidized LDL particles, non-HDL cholesterol, remnant cholesterol, glucose, insulin, blood pressure, and pulse pressure. After 16 months, significant decreases were seen in body weight (-1.8 kg), body mass index (-0.6 kg/m2), and measured LDL cholesterol (-12 mg/dl). Increases in the healthful plant-based diet index were associated with risk marker improvements. Conclusions The recommendation of moving towards a plant-based diet appears acceptable and actionable and may improve body weight. The healthful plant-based diet index can be a useful parameter for intervention studies. Y1 - 2022 U6 - http://dx.doi.org/10.1002/osp4.649 ER -