TY - GEN A1 - Thomas, Laura A1 - Haferkamp, Julia Elen A1 - Buhlmann, Ulrike T1 - Escaping reality - do procrastinators consume more cannabis and alcohol than their peers? Checking on a common stereotype. Poster präsentiert auf der 11th Biennial Procrastination Research Conference in Sheffield, UK. Y1 - 2019 ER - TY - GEN A1 - Engberding, Margarita A1 - Thomas, Laura A1 - Höcker, Anna A1 - Haferkamp, Julia Elen A1 - Förster, Stephan A1 - Rist, Fred A1 - Buhlmann, Ulrike T1 - Procrastination in clinical context: Prevalence and diagnostic findings in psychotherapy outpatients. Präsentation eines Posters auf der 10th Biennial Procrastination Research Conference in Chicago, USA. Y1 - 2019 ER - TY - JOUR A1 - Gadosey, Christopher K. A1 - Grunschel, Carola A1 - Kegel, Lena S. A1 - Schnettler, Theresa A1 - Turhan, Derya A1 - Scheunemann, Anne A1 - Bäulke, Lisa A1 - Thomas, Laura A1 - Buhlmann, Ulrike A1 - Dresel, Markus A1 - Fries, Stefan A1 - Leutner, Detlev A1 - Wirth, Joachim T1 - Study satisfaction among university students during the COVID-19 pandemic: Longitudinal development and personal-contextual predictors. JF - Frontiers in Psychology Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:836-opus-179202 IS - 13 ER - TY - JOUR A1 - Turhan, Derya A1 - Schnettler, Theresa A1 - Scheunemann, Anne A1 - Gadosey, Christopher A1 - Kegel, Lena A1 - Bäulke, Lisa A1 - Thies, Daniel Oliver A1 - Thomas, Laura A1 - Buhlmann, Ulrike A1 - Dresel, Markus A1 - Fries, Stefan A1 - Leutner, Detlev A1 - Wirth, Joachim A1 - Grunschel, Carola T1 - University students' profiles of burnout symptoms amid the COVID-19 pandemic in Germany and their relation to concurrent study behavior and experiences. JF - International Journal of Educational Research Y1 - 2022 U6 - http://dx.doi.org/10.1016/j.ijer.2022.102081 IS - 116 ER - TY - GEN A1 - Sanfilippo-Schulz, Jessica T1 - “Hungry for a home in Susan Abulhawa’s ‘Memories in an Un-Palestinian Story, in a Can of Tuna’.” The Diasporic Plate: Food in the Contemporary Diasporic World in Times of Crisis (28 November 2020) Institute of Modern Languages Research, London KW - Food, Susan Abulhawa, adoption, childhood Y1 - 2020 ER - TY - GEN A1 - Sanfilippo-Schulz, Jessica T1 - “Growing up in the “Cross-Culture.” Transnational Literature and Writing: Follow the Sun (29 January 2021) Transnational Literature, Paper Nations, TRACE at Bath Spa University KW - Cross cultural kids Y1 - 2022 ER - TY - GEN A1 - Sanfilippo-Schulz, Jessica T1 - Q and A for series 'Thrive as a global family' of F.L.O.C.K. of United Nations World Food Programme, Rome KW - Third culture kids, memoirs, childhoods on the move Y1 - 2022 ER - TY - GEN A1 - Sanfilippo-Schulz, Jessica T1 - Memoirs to Understand the TCK and CCK Experience KW - Memoirs, TCK, CCK Y1 - 2022 ER - TY - JOUR A1 - Sanfilippo-Schulz, Jessica T1 - Riccardino - The Dead Lines of Andrea Camilleri JF - Crossed Lines Exhibition, AHRC-funded research project led by Dr Sarah Jackson (Nottingham Trent University) in partnership with the Science Museum and the BT Archives KW - Translation, telephone lines, Andrea Camilleri, Montalbano Y1 - 2020 UR - https://crossedlines.co.uk/online-exhibition/ ER - TY - JOUR A1 - Sanfilippo-Schulz, Jessica T1 - Daughters and Mothers JF - Corona Lost and Found: A Pandemic Archive. Rebecca Adelman (Ed.) KW - Creative writing, lock-down Y1 - 2020 UR - https://pandemicarchive.com/daughters-and-mothers/ ER - TY - JOUR A1 - Sanfilippo-Schulz, Jessica T1 - Haiku of Maladisms JF - Satura KW - Creative writing, haiku, Covid-19 Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:836-opus-170416 SN - 2701-0201 VL - 3 SP - 35 EP - 35 ER - TY - JOUR A1 - Sanfilippo-Schulz, Jessica T1 - Escaping National Tags and Embracing Diversity: Third Culture Kid Songwriters JF - Open Cultural Studies KW - Third Culture Kids songwriters Y1 - 2018 UR - https://doi.org/10.1515/culture-2018-0003 SN - 2451-3474 VL - 2 IS - 1 PB - de Gruyter ER - TY - JOUR A1 - Sanfilippo-Schulz, Jessica T1 - Marketing Transnational Childhoods: The Bio Blurbs of Third Culture Novelists JF - Transnational Literature KW - Third Culture Literature & Kids KW - Bio Blurbs Y1 - 2016 UR - https://core.ac.uk/download/pdf/81291254.pdf VL - 9 IS - 1 ER - TY - JOUR A1 - Sanfilippo-Schulz, Jessica T1 - Big Small Steps: Childhoods on the Move JF - Satura KW - Third culture kids KW - Third Culture Literature Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:836-opus-169858 SN - 2701-0201 VL - 1 SP - 69 EP - 76 PB - University of Münster, English Seminar ER - TY - JOUR A1 - Sanfilippo-Schulz, Jessica T1 - Becoming Cross-Cultural Kids in K. J. Fowler’s ‘We Are All Completely Beside Ourselves’ JF - Junctions: Graduate Journal of the Humanities KW - Third culture kids KW - critical animal studies KW - cross cultural kids KW - childhood studies KW - Karen J. Fowler Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:836-opus-169847 SN - 2468-8282 VL - 4 IS - 1 SP - 23 EP - 42 PB - The Graduate School of Humanities, Utrecht University ER - TY - CHAP A1 - Sanfilippo-Schulz, Jessica ED - Soyinka, Bambo ED - Palmer, Grace T1 - Transnational Writing to Aminatta Forna T2 - Transnational Literature KW - Aminatta Forna, transnationalism, third culture kids Y1 - 2021 U6 - http://dx.doi.org/10.33008/TNL.2021.13012 SN - 1836-4845 PB - Research Centre for Transcultural Creativity and Education (TRACE) CY - Bath Spa University ER - TY - JOUR A1 - Sanfilippo-Schulz, Jessica T1 - A Victorious Roman Holiday: Life Writing and Loving Beyond Boundaries JF - European Journal of Life Writing KW - Creative writing KW - life writing KW - transnational love Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:836-opus-169763 SN - 2211-243X VL - 10 ER - TY - JOUR A1 - Müller, Carsten T1 - Personality Traits and Physical Activity: Insights from German University Students JF - European Journal of Investigation in Health, Psychology and Education N2 - This study explores the intriguing relationship between personality traits, self-rated fitness (SRF), and physical activity (PA) variables among German university students (N = 4244) and sheds light on the impact of personality on adherence to PA guidelines. Employing an online cross-sectional study, the short-form of the Big Five Inventory-2 assessed five domains of personality traits (Extraversion, Negative Emotionality, Agreeableness, conscientiousness, and Open-Mindedness). PA, including sitting time, was assessed using the International Physical Activity Questionnaire (short-form). SRF and muscle-strengthening activities (MSA) were assessed with one item each. Multiple linear and logistic regression analyses examined associations of individual personality trait domains and all domains combined with SFR, PA variables, and adherence to PA guidelines, controlling for sociodemographic, behavioral, and (mental) health covariates. Most reliably, Extraversion and Conscientiousness revealed positive associations with PA variables, while Negative Emotionality yielded inverse relationships with PA variables. For instance, each unit increase in Extraversion corresponded to an additional 17 min of weekly MSA. On the contrary, daily sitting time was unrelated to personality. Of note, high Open-Mindedness was associated with lower odds for adhering to current PA guidelines. The findings have implications for developing targeted interventions that promote a physically active lifestyle and support students’ well-being and academic success. KW - five factor model KW - health psychology KW - exercise KW - public health KW - physical activity guidelines Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:836-opus-168729 VL - 13 IS - 8 SP - 1423 EP - 1440 ER - TY - JOUR A1 - Winter, Corinna A1 - Müller, Carsten A1 - Brandes, Mirko A1 - Brinkmann, Anja A1 - Hoffmann, Christiane A1 - Hardes, Jendrik A1 - Gosheger, Georg A1 - Boos, Joachim A1 - Rosenbaum, Dieter T1 - Level of activity in children undergoing cancer treatment JF - Pediatric Blood & Cancer N2 - Background The diagnosis of cancer bears severe implications for pediatric patients. One immense restriction consists in a reduced level of activity due to different factors. Physical activity affects various aspects of development and can be regarded as an essential part of a child's life. In the present study physical activity in patients undergoing cancer therapy was quantified in order to determine the extent of the restriction and to provide baseline information for the assessment of possible interventions. Procedure Physical activity in 80 patients and 45 healthy children matched for age and gender was measured using the StepWatch 3™ Activity Monitor (SAM, OrthoCare Innovations). Results Pediatric cancer patients, at 2,787 gait cycles (gcs) per day, were significantly less active than their healthy counterparts (8,096 gcs). Patients were significantly more active at home than during inpatient stays (3,185 gcs compared to 1,830 gcs), and patients with bone tumors were less active than those with leukemia regarding both, the amount (1,849 gcs vs. 2,992 gcs) and the intensity of activity. Conclusion The present study quantified an often observed but so far hardly assessable problem. Activity in cancer patients is considerably reduced and patients with bone tumors are at increased risk from the detrimental effects of prolonged inactivity. Both our findings and the accepted fact that activity is an essential element of child development confirm the need for interventions tailored to a patient's needs and abilities during the course of treatment. KW - bone tumor KW - childhood cancer KW - leukemia KW - physical activity Y1 - 2009 U6 - http://dx.doi.org/10.1002/pbc.22055 VL - 53 IS - 3 SP - 438 EP - 443 ER - TY - JOUR A1 - Winter, Corinna A1 - Müller, Carsten A1 - Hoffmann, Christiane A1 - Boos, Joachim A1 - Rosenbaum, Dieter T1 - Physical activity and childhood cancer JF - Pediatric Blood & Cancer N2 - This review provides a survey of studies investigating physical activity and exercise interventions in patients during tumor treatment and survivors of childhood cancer. PubMed and Medline databases were searched using relevant terms. References of selected papers were tracked. A total of 28 studies could be identified. Seventeen studies investigated physical activity, 11 studies determined the effect of activity enhancing interventions during and after therapy. Even though most studies showed limitations and results were not consistent, considerably reduced physical activity is highly probable in patients during and after therapy. Studies on interventions provided promising results and revealed challenges to be faced. Pediatr Blood Cancer KW - activity promotion KW - childhood cancer KW - exercise interventions KW - physical activity Y1 - 2010 U6 - http://dx.doi.org/10.1002/pbc.22271 VL - 54 IS - 4 SP - 501 EP - 510 ER - TY - JOUR A1 - Müller, Carsten A1 - Winter, Corinna A1 - Klein, Dieter A1 - Fuchs, Katharina A1 - Schmidt, Carolin A1 - Schulte, Tobias L. A1 - Bullmann, Viola A1 - Rosenbaum, Dieter T1 - Objective assessment of brace wear times and physical activities in two patients with scoliosis JF - Biomedizinische Technik N2 - Conservative treatment of adolescent idiopathic scoliosis consists of therapeutic exercise and the application of braces. The effectiveness of bracing mainly depends on patient compliance, which can be determined by means of temperature sensors. This methodological paper describes the feasibility of objectively determining compliance and daily physical activities before and during conservative scoliosis treatment, being a relevant indicator for quality of life in children and adolescents. One patient with low compliance (61.4±24.9%) reduced her activity level during bracing by 50.1%, whereas another patient with a satisfactory compliance (85.7±19.5%) increased her daily activity level by 33.7% during conservative treatment. KW - bracing KW - compliance KW - conservative scoliosis treatment KW - physical activity KW - thermobutton Y1 - 2010 U6 - http://dx.doi.org/10.1515/BMT.2010.026 VL - 55 IS - 2 SP - 117 EP - 120 ER - TY - JOUR A1 - Winter, Corinna A1 - Brandes, Mirko A1 - Müller, Carsten A1 - Schubert, Tim A1 - Ringling, Michael A1 - Hillmann, Axel A1 - Rosenbaum, Dieter A1 - Schulte, Tim T. T1 - Walking ability during daily life in patients with osteoarthritis of the knee or the hip and lumbar spinal stenosis JF - BMC Musculoskeletal Disorders N2 - Background Degenerative musculoskeletal disorders are among the most frequent diseases occurring in adulthood, often impairing patients' functional mobility and physical activity. The aim of the present study was to investigate and compare the impact of three frequent degenerative musculoskeletal disorders -- knee osteoarthritis (knee OA), hip osteoarthritis (hip OA) and lumbar spinal stenosis (LSS) -- on patients' walking ability. Methods The study included 120 participants, with 30 in each patient group and 30 healthy control individuals. A uniaxial accelerometer, the StepWatch™ Activity Monitor (Orthocare Innovations, Seattle, Washington, USA), was used to determine the volume (number of gait cycles per day) and intensity (gait cycles per minute) of walking ability. Non-parametric testing was used for all statistical analyses. Results Both the volume and the intensity of walking ability were significantly lower among the patients in comparison with the healthy control individuals (p < 0.001). Patients with LSS spent 0.4 (IQR 2.8) min/day doing moderately intense walking (>50 gait cycles/min), which was significantly lower in comparison with patients with knee and hip OA at 2.5 (IQR 4.4) and 3.4 (IQR 16.1) min/day, respectively (p < 0.001). No correlations between demographic or anthropometric data and walking ability were found. No technical problems or measuring errors occurred with any of the measurements. Conclusions Patients with degenerative musculoskeletal disorders suffer limitations in their walking ability. Objective assessment of walking ability appeared to be an easy and feasible tool for measuring such limitations as it provides baseline data and objective information that are more precise than the patients' own subjective estimates. In everyday practice, objective activity assessment can provide feedback for clinicians regarding patients' performance during everyday life and the extent to which this confirms the results of clinical investigations. The method can also be used as a way of encouraging patients to develop a more active lifestyle. KW - Gait Cycle KW - Lumbar Spinal Stenosis KW - Walking Ability KW - Healthy Control Individual KW - Zygapophyseal Joint Y1 - 2010 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:836-opus-168673 VL - 11 IS - 233 SP - 1 EP - 7 ER - TY - JOUR A1 - Müller, Carsten A1 - Winter, Corinna A1 - Rosenbaum, Dieter A1 - Boos, Joachim A1 - Gosheger, Georg A1 - Hardes, Jendrik A1 - Vieth, Volker T1 - Early decrements in bone density after completion of neoadjuvant chemotherapy in pediatric bone sarcoma patients JF - BMC Musculoskeletal Disorders N2 - Background Bone mineral density (BMD) accrual during childhood and adolescence is important for attaining peak bone mass. BMD decrements have been reported in survivors of childhood bone sarcomas. However, little is known about the onset and development of bone loss during cancer treatment. The objective of this cross-sectional study was to evaluate BMD in newly diagnosed Ewing's and osteosarcoma patients by means of dual-energy x-ray absorptiometry (DXA) after completion of neoadjuvant chemotherapy. Methods DXA measurements of the lumbar spine (L2-4), both femora and calcanei were performed perioperatively in 46 children and adolescents (mean age: 14.3 years, range: 8.6-21.5 years). Mean Z-scores, areal BMD (g/cm2), calculated volumetric BMD (g/cm3) and bone mineral content (BMC, g) were determined. Results Lumbar spine mean Z-score was -0.14 (95% CI: -0.46 to 0.18), areal BMD was 1.016 g/cm2 (95% CI: 0.950 to 1.082) and volumetric BMD was 0.330 g/cm3 (95% CI: 0.314 to 0.347) which is comparable to healthy peers. For patients with a lower extremity tumor (n = 36), the difference between the affected and non-affected femoral neck was 12.1% (95% CI: -16.3 to -7.9) in areal BMD. The reduction of BMD was more pronounced in the calcaneus with a difference between the affected and contralateral side of 21.7% (95% CI: -29.3 to -14.0) for areal BMD. Furthermore, significant correlations for femoral and calcaneal DXA measurements were found with Spearman-rho coefficients ranging from ρ = 0.55 to ρ = 0.80. Conclusions The tumor disease located in the lower extremity in combination with offloading recommendations induced diminished BMD values, indicating local osteopenia conditions. However, the results revealed no significant decrements of lumbar spine BMD in pediatric sarcoma patients after completion of neoadjuvant chemotherapy. Nevertheless, it has to be taken into account that bone tumor patients may experience BMD decrements or secondary osteoporosis in later life. Furthermore, the peripheral assessment of BMD in the calcaneus via DXA is a feasible approach to quantify bone loss in the lower extremity in bone sarcoma patients and may serve as an alternative procedure, when the established assessment of femoral BMD is not practicable due to endoprosthetic replacements. KW - Bone Mineral Density KW - Lumbar Spine Bone Mineral Density KW - Areal Bone Mineral Density KW - Osteosarcoma Patient KW - Bone Mineral Density Loss Y1 - 2010 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:836-opus-168661 VL - 11 IS - 287 SP - 1 EP - 8 ER - TY - JOUR A1 - Winter, Corinna A1 - Müller, Carsten A1 - Hardes, Jendrik A1 - Boos, Joachim A1 - Gosheger, Georg A1 - Rosenbaum, Dieter T1 - Pediatric patients with a malignant bone tumor: when does functional assessment make sense? JF - Supportive Care in Cancer N2 - Purpose The diagnosis of a malignant bone tumor in the lower limb is a risk factor for physical disability, limiting physical performance. Walking ability especially, which is essential for most activities of daily living, is limited in those patients. In the present study, the extent of limitations during the course of treatment was investigated to determine when the assessment of functional parameters is meaningful in those patients. Methods In the present study, activity levels were determined in 20 patients with a malignant bone tumor in the lower limb who received endoprosthetic replacement of the affected bone and in 20 healthy individuals. A uniaxial accelerometer was used to investigate patients at five different time points after surgery. Results Patients performed significantly less amounts and intensities of activity than control individuals at all measurements. Significant increases in the volume of activity were observed after cessation of treatment. However, the intensity of activity only showed minor increases. Patients experiencing complications of surgery revealed greater restriction than those without even 18 months after surgery. Conclusions After cessation of treatment for their disease, patients recovered markedly and showed great improvements in physical activity. However, some limitations appeared to persist. Comparisons with patients with longer follow-up revealed that meaningful functional assessment does not make sense within the first 12 months after surgery. More research is needed to show if longer follow-up periods reveal further improvements. Based on such information, it should be more promising to develop individually tailored activity recommendations and intervention programs. KW - Malignant bone tumor KW - Endoprosthetic replacement KW - Functional assessment KW - Physical activity Y1 - 2011 U6 - http://dx.doi.org/10.1007/s00520-010-1077-5 VL - 20 SP - 127 EP - 133 ER - TY - JOUR A1 - Müller, Carsten A1 - Fuchs, Katharina A1 - Winter, Corinna A1 - Rosenbaum, Dieter A1 - Schmidt, Carolin A1 - Bullmann, Viola A1 - Schulte, Tobias T1 - Prospective evaluation of physical activity in patients with idiopathic scoliosis or kyphosis receiving brace treatment JF - European Spine Journal N2 - Bracing is an established method of conservative treatment for adolescent idiopathic scoliosis and kyphosis. Compliance among adolescents is frequently inadequate due to the discomfort of wearing a brace, cosmetic issues, and fear on the part of patients and parents that bracing may reduce everyday physical activities. The aim of this prospective, controlled study was to objectify the impact of spinal bracing on daily step activity in patients receiving conservative treatment for adolescent idiopathic scoliosis (AIS) or adolescent kyphosis (AK). Forty-eight consecutive patients (mean age 13.4 ± 2.3 years), consisting of 38 AIS patients (33 girls, 5 boys) and 10 AK patients (6 girls, 4 boys) were included. Once the decision to carry out bracing had been taken and while the patients were waiting for the individual brace to be built, step activity was assessed without braces by means of step activity monitoring (SAM) for seven consecutive days. After 8 weeks of brace wearing, step activity was assessed during regular brace treatment, again for seven consecutive days. In addition, brace-wearing times were simultaneously recorded using temperature probes implanted in the braces to measure compliance. Before and during brace treatment, patients completed the Scoliosis Research Society (SRS-22) questionnaire. The SAM was worn for an average of 12.7 ± 1.5 h/day during the first measurement and 12.3 ± 1.9 h on average during the second measurement. The mean gait cycles (GCs) per day and per hour before treatment were 5,036 ± 1,465 and 395 ± 105, respectively. No significant reduction in step activity was found at the follow-up measurement during bracing, at 4,880 ± 1,529 GCs/day and 403 ± 144 GCs/h. Taking the 23-h recommended time for brace wearing as a basis (100%), patients wore the brace for 72.7 ± 27.6% of the prescribed time, indicating an acceptable level of compliance. Girls showed a higher compliance level (75.6 ± 25.6%) in comparison with boys (56.7 ± 31.9%), although the difference was not significant (P = 0.093). The SRS-22 total score showed no differences between the two measurements (2.57 ± 0.23 vs. 2.56 ± 0.28). Implementing a simultaneous and objective method of assessing step activity and brace-wearing times in everyday life proved to be feasible, and it expands the information available regarding the impact of bracing on patients’ quality of life. The results clearly show that brace treatment does not negatively interfere with daily step activity in AIS and AK patients. This is an important finding that should help reduce patients’ and parents’ worries concerning bracing. KW - Step activity monitoring (SAM) KW - Bracing KW - Compliance KW - Idiopathic adolescent scoliosis KW - Idiopathic adolescent kyphosis Y1 - 2011 U6 - http://dx.doi.org/10.1007/s00586-011-1791-9 VL - 20 SP - 1127 EP - 1136 ER - TY - JOUR A1 - Corinna, Winter A1 - Carsten, Müller A1 - Hardes, Jendrik A1 - Boos, Joachim A1 - Gosheger, Georg A1 - Rosenbaum, Dieter T1 - The effect of individualized exercise interventions during treatment in pediatric patients with a malignant bone tumor JF - Supportive Care in Cancer N2 - Background While research on exercise interventions during anticancer treatment is well-established in adults, only very few studies exist in children. However, pediatric patients experience great limitations to being physically active, and appropriate interventions are desired. Procedure The present study aimed at investigating the effects of individualized exercise interventions during inpatient stays on pediatric patients with a malignant bone tumor. The parameter of interest was physical activity (PA). Patients’ PA during home stays was assessed 6 weeks as well as 3, 6, 12, and 18 months post-surgery. Patients were distinguished into an intervention group and a control group. All patients received endoprosthetic replacement of the affected bone in the same institution. Results A constant increase in all PA parameters was observed during follow-up. Exercise interventions were possible and appeared worthwhile. The intervention group showed better PA results at all measurements; however, no significant differences between groups were found. Furthermore, differences decreased especially after the cessation of the intervention. General problems in reaching appropriate power and compliance were observed. Conclusions Individualized exercise interventions in pediatric bone tumor patients are possible and appear to be beneficial. Such interventions should be implemented in adjuvant care; however, future research is needed to understand more about the effects of different interventions. KW - Malignant bone tumor KW - Physical activity KW - Exercise intervention Y1 - 2013 U6 - http://dx.doi.org/10.1007/s00520-012-1707-1 VL - 21 SP - 1629 EP - 1636 ER - TY - JOUR A1 - Müller, Carsten A1 - Winter, Corinna A1 - Boos, Joachim A1 - Gosheger, Georg A1 - Hardes, Jendrik A1 - Vieth, Volker A1 - Rosenbaum, Dieter T1 - Effects of an exercise intervention on bone mass in pediatric bone tumor patients JF - International Journal of Sports Medicine N2 - The aim was to evaluate the effects of additional exercises during inpatient stays on bone mass in pediatric bone tumor patients. 21 patients were non-randomly allocated either to the exercise group (n=10) or the control group (n=11). DXA of the lumbar spine, the non-affected femur and both calcanei was performed after completion of neoadjuvant chemotherapy (baseline), as well as 6 and 12 months after baseline. Bone mineral content (BMC), bone mineral density (BMD) and height-corrected lumbar spine Z-scores were determined. Group changes after 6 and 12 months were compared by covariance analyses. Additionally, daily physical activities (PA) were assessed by means of accelerometry. After adjusting for initial age, height and weight, mean reductions in lumbar spine and femoral BMC were lower in the exercise group (not significant). Effect sizes during the observational period for lumbar spine and femur BMC were generally small (partial η²=0.03). The exercise group demonstrated substantially higher PA levels in terms of gait cycles per day, per hour and moderate PA (activities above 40 gait cycles per minute). Additional exercises for bone tumor patients are feasible during hospitalization. Though the intervention did not influence BMC, it appeared beneficial regarding PA promotion with respect to volume and intensity. KW - bone mass KW - training program KW - physical activity KW - sarcoma KW - children Y1 - 2014 U6 - http://dx.doi.org/10.1055/s-0033-1358475 VL - 35 IS - 08 SP - 696 EP - 703 ER - TY - JOUR A1 - Kösters, Clemens A1 - Bockholt, Sebastian A1 - Müller, Carsten A1 - Winter, Corinna A1 - Rosenbaum, Dieter A1 - Raschke, Michael J. A1 - Ochmann, Sabine T1 - Comparing the outcomes between Chopart, Lisfranc and multiple metatarsal shaft fractures JF - Archives of Orthopaedic and Trauma Surgery N2 - Objectives Complex midfoot injuries could lead to severe functional impairment of mobility and quality of daily living. Aim of this study was to compare the clinical and functional outcomes of Chopart, Lisfranc fractures and multiple metatarsal shaft fractures. Design Retrospective case series. Setting Level one trauma center. Intervention Open or closed reduction and internal fixation with screws, K-wires, plates, external fixation or combination of different technics. Main outcome measurements The American Orthopaedic Foot and Ankle Society (AOFAS) Midfoot Score and the Maryland Foot Score were used to assess pain and functional outcome. 3D gait analysis, pedobarographic analysis and radiologic examinations were performed. The activity level was measured by a step counting accelerometer. All results were compared to an age-matched healthy control group. Results 24 patients with a median age of 44 years (16–72) were included: 12 patients with multiple metatarsal shaft fractures, 6 patients with Chopart and 6 patients with Lisfranc fractures. The median follow-up was 2.6 years. The pedobarographic analysis reports reduced contact time of the total foot (p = 0.08), the forefoot (p = 0.008) and the hallux (p = 0.015) for the injured foot. A median score of 64 for the SF-36, 64 for the AOFAS Midfoot Score and 73 for the Maryland Foot Score indicated a poor restoration of foot function. Multiple metatarsal shaft fractures presented a significantly lower walking speed (p = 0.03) and cadence (p = 0.04). Conclusion The worst results were reported for multiple metatarsal shaft fractures on outcome scores, pedobarography, gait analysis and activity. Metatarsal serial fractures should not be underestimated as well as Chopart and Lisfranc fractures. KW - Multiple metatarsal fractures KW - Gait analysis KW - Pedobarography KW - Chopart KW - Lisfranc Y1 - 2014 U6 - http://dx.doi.org/10.1007/s00402-014-2059-8 VL - 134 SP - 1397 EP - 1404 ER - TY - JOUR A1 - Müller, Carsten A1 - Brandes, Mirko T1 - The effect of kinesiology tape applications on performance in amateur soccer and team handball JF - Journal of Human Kinetics N2 - Evidence supporting performance enhancing effects of kin esiotape in sports is missing . The aims of this studywere to evaluate effects of kinesiotape applications with regard to shooting and throwing performance in 26 amateursoccer and 32 handball players, and to further investigate if these effects were influenced by the players’ level ofperformance. Ball speed as the primary outcome and accuracy of soccer kicks and handball throws were analyzed withand without kinesiotape by means of radar units and video recordings. The application of kinesiotapes significantlyincreased ball speed in soccer by 1.4 km/h (p=0.047) and accuracy with a lesser di stance from the target by -6.9 cm(p=0.039). Ball velocity in handball throws also signific antly increased by 1.2 km/h (p=0.013), while accuracy wasdeteriorated with a greater distance from the target by 3.4 cm (p=0.005). Larger effects with respect to ball speed werefound in players with a lower performance level in kick ing (1.7 km/h, p=0.028) and throwing (1.8 km/h, p=0.001)compared with higher level soccer and handball players (1.2 km/h, p=0.346 and 0.5 km/h, p=0.511, respectively). Inconclusion, the applications of kinesiot ape used in this study might have beneficial effects on performance in amateursoccer, but the gain in ball speed in handball is counterac ted by a significant deterioration of accuracy. Subgroupanalyses indicate that kinesiotape may yield larger effects on ball velocity in athletes with lower kicking and throwingskills. KW - athletic performance KW - proprioception KW - elastic bandage KW - sports equipment KW - soccer Y1 - 2015 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:836-opus-168553 VL - 49 IS - 1 SP - 119 EP - 129 ER - TY - JOUR A1 - Müller, Carsten A1 - Krauth, Konstantin A. A1 - Gerß, Joachim A1 - Rosenbaum, Dieter T1 - Physical activity and health-related quality of life in pediatric cancer patients following a 4-week inpatient rehabilitation program JF - Supportive Care in Cancer N2 - Abstract Purpose Chronic health conditions and impaired quality of life are commonly experienced in childhood cancer survivors. While rehabilitation clinics support patients in coping with the disease, studies evaluating an inpatient rehabilitation program on promoting physical activity (PA) and health-related quality of life (HRQoL) are missing. Methods A 4-week inpatient rehabilitation program was prospectively evaluated. One hundred fifty patients with leukemia or lymphoma (N = 86), brain tumors (N = 38), and sarcomas (N = 26) were enrolled on average 17 months after cessation of acute medical treatment. PA amount and cadence (indicating the intensity of walking activity) using the StepWatch™ 3 Activity Monitor and HRQoL global and physical well-being scores using the KINDL® questionnaire were assessed before, immediately after, and 6 and 12 months following the program and analyzed using multiple linear mixed models. Results Significant effects on PA were only found at 12-month follow-up for amount and cadence variables (all p < 0.05). While leukemia and lymphoma patients revealed the highest PA level throughout the study, rehabilitation effects were more pronounced for cadence variables in brain tumor and sarcoma patients. The rehabilitation program had immediate (t = 4.56, p < 0.001) and sustainable effects on HRQoL global scores (6-month follow-up, t = 4.08, p < 0.001; 12-month follow-up, t = 3.13, p < 0.006). Conclusions Immediate and sustainable increases in HRQoL indicate that a 4-week rehabilitation program is beneficial for improving psychosocial well-being, while the significant increase in PA levels could be related to general recovery as well. The lack of a control group hampers the evaluation of the rehabilitation program on promoting PA levels in pediatric cancer patients. KW - physical activity KW - quality of life KW - rehabilitation KW - pediatric oncology KW - childhood cancer Y1 - 2016 UR - https://link.springer.com/article/10.1007/s00520-016-3198-y#citeas U6 - http://dx.doi.org/10.1007/s00520-016-3198-y VL - 24 SP - 3793 EP - 3802 ER - TY - JOUR A1 - Müller, Carsten A1 - Rosenbaum, Dieter A1 - Krauth, Konstantin A. T1 - Prospective Evaluation of Postural Control and Gait in Pediatric Patients with Cancer After a 4-Week Inpatient Rehabilitation Program JF - American journal of physical medicine & rehabilitation / Association of Academic Physiatrists N2 - Objective The aim of the study was to investigate the effects of a 4-wk inpatient rehabilitation program on postural control and gait in pediatric patients with cancer. Design Eighty-eight patients with brain tumors (n = 59) and bone/soft tissue sarcomas (n = 29) were evaluated. Postural control was assessed examining the velocity of the center of pressure and single-leg stance time on a pressure distribution platform. Walk ratio, a measure of neuromotor control, was used to evaluate intervention effects on gait. Results Repeated measures analysis of variance showed improvements in postural control measures, indicated by a decrease in velocity of center of pressure of −0.4 cm/sec (F1,80 = 7.175, P = 0.009, ηp2 = 0.082) and increase in single-leg stance time (mean [median] = 1.1 [2.6] sec, respectively; F1,80 = 12.617, P = 0.001, ηp2 = 0.136). Walk ratio increased by 0.2 mm/steps per min (F1,82 = 3.766, P = 0.056, ηp2 = 0.044). Mean changes in dependent variables did not differ between both patient groups (P > 0.05). Conclusions The results indicate benefits of an inpatient rehabilitation program comprising standard physical therapy as well as aquatic and hippo therapy on postural control and gait after treatment of pediatric patients with cancer. KW - Rehabilitation KW - Pediatrics KW - Postural Balance KW - Gait Y1 - 2017 UR - https://journals.lww.com/ajpmr/Abstract/2017/09000/Prospective_Evaluation_of_Postural_Control_and.8.aspx U6 - http://dx.doi.org/10.1097/PHM.0000000000000729 VL - 96 IS - 9 SP - 646 EP - 653 ER - TY - CHAP A1 - Müller, Carsten A1 - Hendker, Anna A1 - Szwajca, Sebastian A1 - Zentgraf, Karen T1 - The relation between agility performance (changes) and core stability in elite handball and volleyball players T2 - Conference: Cogito, ergo commoveo - Multitasking im Sport N2 - Although practical guidelines refer to core stability as a necessity for agility performance, it is not explicitly considered a prerequisite for agility performance development. Therefore, we assume an essential role of the core regarding the development of agility performance. Y1 - 2017 UR - https://www.feldhaus-verlag.de/sportwissenschaft/schriftreihen/dvs-schriftenreihe/470/cogito-ergo-commoveo-multitasking-im-sport?number=17419 SN - 978-3-88020-648-9 PB - Feldhaus, Edition Czwalina CY - Hamburg ER - TY - JOUR A1 - Ferger, Katja A1 - Hackbarth, Michael A1 - Mylo, Max David A1 - Müller, Carsten A1 - Zentgraf, Karen T1 - Measuring temporal and spatial accuracy in trampolining JF - Sports Engineering N2 - A new measurement system (horizontal displacement, time of flight, synchronicity—HDTS) was investigated regarding the latest changes to the international evaluation rules in trampoline gymnastics. It allows for the real-time measurement of objective criteria, such as flight time and landing position, without affecting the gymnast. The aim of this study was to investigate the temporal and spatial accuracy of a measurement tool via cross-validation. Temporal precision was additionally tested via high-speed video landing and takeoff, while a three-dimensional motion capturing system was incorporated for spatial precision. The Bland–Altman “limit of agreement approach” was used for the assessment of congruence between the measurement systems. The new measurement system presented an average spatial deviation of 3.2 cm and a temporal deviation between − 5.8 and + 6.4 ms for the landing and − 11.3 and + 11.3 ms for the takeoff. Given its temporal and spatial accuracy in determining flight time and landing position as identified through cross-validation, the novel HDTS system proved to be suitable for its use in trampoline competitions. KW - trampolining KW - measurement device KW - accuracy KW - limit of agreement Y1 - 2019 UR - https://link.springer.com/article/10.1007/s12283-019-0310-9 U6 - http://dx.doi.org/10.1007/s12283-019-0310-9 VL - 22 IS - 18 SP - 1 EP - 7 ER - TY - JOUR A1 - Müller, Carsten A1 - Zentgraf, Karen T1 - Neck and Trunk Strength Training to Mitigate Head Acceleration in Youth Soccer Players JF - he Journal of Strength and Conditioning Research N2 - Heading in soccer involves repetitive head accelerations that may be detrimental for brain health. One way to mitigate adverse effects may be to increase head-neck stabilization and thus reduce the kinematic response after intentional headers. This study aimed to (a) assess associations between neck strength and head kinematics and (b) evaluate an exercise intervention designed to increase strength and attenuate head acceleration during intentional heading in youth soccer players. In 22 athletes, we used accelerometers to assess associations between neck strength and peak linear acceleration (PLA). We attached the accelerometers to the occiput and sternum, allowing us to differentiate between total, trunk, and head PLA. Longitudinally, we evaluated the effects of a 14-week twice-weekly resistance training in a subsample of 14 athletes compared with regular soccer training (N = 13). Results showed that female athletes had lower isolated neck strength (p ≤ 0.004), lower functional neck strength (p ≤ 0.017), and higher total PLA during purposeful headers compared with males (17.2 ± 3.5 g and 13.0 ± 2.3 g, respectively, at 9.6 m·s−1 ball velocity during impact; p = 0.003). The intervention group showed moderate to large strength gains (η = 0.16–0.42), resulting in lower PLA (total −2.4 g, trunk −0.8 g, and head −1.5 g) during headers. We conclude that a resistance training focusing on cervical and trunk musculature is practicable in youth soccer, elicits strength gains, and helps to mitigate PLA during purposeful heading. Results should encourage youth strength and conditioning professionals to incorporate neck exercises as a risk reduction strategy into their training routine. KW - resistance exercise KW - header KW - ball velocity KW - neuromuscular stabilization KW - cervical strength Y1 - 2021 UR - https://journals.lww.com/nsca-jscr/Abstract/2021/12002/Neck_and_Trunk_Strength_Training_to_Mitigate_Head.13.aspx U6 - http://dx.doi.org/10.1519/JSC.0000000000003822 VL - 35 SP - S81 EP - S89 ER - TY - JOUR A1 - Tan, Shu Ling A1 - Jetzke, Malte A1 - Vergeld, Vera A1 - Müller, Carsten T1 - Independent and Combined Associations of Physical Activity, Sedentary Time, and Activity Intensities With Perceived Stress Among University Students: Internet-Based Cross-Sectional Study JF - JMIR Public Health and Surveillance N2 - Background: Mental health is an emerging topic on university campuses, with students reporting higher levels of psychological distress than the general population of the same age. Increasing physical activity and reducing sedentary time have been proved promising measures to promote mental health in the general population. However, to derive and implement effective measures to promote mental health among university students, further exploration of the associations between physical activity, sedentary time, and perceived stress in this specific setting is needed. Objective: This study aims to identify associations between physical activity, sedentary time, and perceived stress after controlling for sociodemographic and behavioral variables among university students in Germany. We hypothesize that perceived stress is inversely related to physical activity and positively associated with sedentary time. Furthermore, we hypothesize that combined associations of concurrently high physical activity and low sedentary time on perceived stress are stronger compared with either alone and that the association between physical activity and perceived stress depends on activity intensity. Methods: We conducted cross-sectional analyses from a large-scale internet-based student health survey (n=4189; response rate=10.0%). Physical activity, sedentary time, and engaging in moderate and vigorous activity intensities were assessed using the International Physical Activity Questionnaire Short Form with categorization into low, intermediate, and high levels. We measured perceived stress using the 10-item Perceived Stress Scale (range 0-40). Results: The results indicate that higher physical activity and lower sedentary time are associated with reduced levels of perceived stress. Following adjustment for gender, BMI, income, fruit and vegetable intake, alcohol consumption, and sleep quality, perceived stress scores were lower for students reporting high physical activity levels and low sedentary time compared with the least active and highly sedentary students (Perceived Stress Scale –2.2, 95% CI –2.9 to –1.5, P<.001 for physical activity and –1.1, CI 95% –1.7 to –0.5, P<.001 for sedentary time). Combined associations with perceived stress revealed that students concurrently reporting high total physical activity and low sedentary time reported the lowest perceived stress scores of all possible combinations following adjustment for confounders (Perceived Stress Scale –3.5, CI 95% –4.6 to –2.5, P<.001 compared with students reporting low physical activity levels and concurrently high sedentary time). Associations between vigorous physical activities and perceived stress were not stronger compared with moderate activity intensities. Conclusions: Self-reported physical activity and low sedentary time are favorably associated with perceived stress, while the intensity of physical activities seems to be of minor importance. These results help to effectively implement health-promoting measures on campus among university students through increasing physical activity and reducing sedentary time. KW - physical activity KW - sedentary time KW - perceived stress KW - university students KW - intensity of physical activity Y1 - 2020 UR - https://publichealth.jmir.org/2020/4/e20119/ U6 - http://dx.doi.org/10.2196/20119 VL - 6 IS - 4 SP - 1 EP - 14 ER - TY - JOUR A1 - Müller, Carsten T1 - External Load Analysis in Beach Handball Using a Local Positioning System and Inertial Measurement Units JF - Sensors N2 - Beach handball is a young discipline that is characterized by numerous high-intensity actions. By following up on previous work, the objective was to perform in-depth analyses evaluating external load (e.g., distance traveled, velocity, changes in direction, etc.) in beach handball players. In cross-sectional analyses, data of 69 players belonging to the German national or prospective team were analyzed during official tournaments using a local positioning system (10 Hz) and inertial measurement units (100 Hz). Statistical analyses comprised the comparison of the first and second set and the effects of age and sex (female adolescents vs. male adolescents vs. male adults) and playing position (goalkeepers, defenders, wings, specialists, and pivots) on external load measures. We found evidence for reduced external workload during the second set of the matches (p = 0.005, ηp2 = 0.09), as indicated by a significantly lower player load per minute and number of changes in direction. Age/sex (p < 0.001, ηp2 = 0.22) and playing position (p < 0.001, ηp2 = 0.29) also had significant effects on external load. The present data comprehensively describe and analyze important external load measures in a sample of high-performing beach handball players, providing valuable information to practitioners and coaches aiming at improving athletic performance in this new sport. KW - performance analysis KW - load analysis KW - player load KW - inertial movement analysis Y1 - 2022 UR - https://www.mdpi.com/1424-8220/22/8/3011 U6 - http://dx.doi.org/10.3390/s22083011 VL - 22 IS - 8 SP - 1 EP - 14 ER - TY - JOUR A1 - Weber, Franziska A1 - Müller, Carsten A1 - Bahns, Carolin A1 - Kopkow, Christian A1 - Färber, Francesca A1 - Gellert, Paul A1 - Otte, Ina A1 - Vollmar, Horst Christian A1 - Brannath, Werner A1 - Diederich, Freya A1 - Kloep, Stephan A1 - Rothgang, Heinz A1 - Dieter, Valerie A1 - Krauß, Inga A1 - Kloek, Corelien A1 - Veenhof, Cindy A1 - Collisi, Sandra A1 - Repschläger, Ute A1 - Böbinger, Hannes A1 - Grüneberg, Christian A1 - Thiel, Christian A1 - Peschke, Dirk T1 - Smartphone-assisted training with education for patients with hip and/or knee osteoarthritis (SmArt-E): study protocol for a multicentre pragmatic randomized controlled trial JF - BMC Musculoskeletal Disorders N2 - Introduction Hip and knee osteoarthritis are associated with functional limitations, pain and restrictions in quality of life and the ability to work. Furthermore, with growing prevalence, osteoarthritis is increasingly causing (in)direct costs. Guidelines recommend exercise therapy and education as primary treatment strategies. Available options for treatment based on physical activity promotion and lifestyle change are often insufficiently provided and used. In addition, the quality of current exercise programmes often does not meet the changing care needs of older people with comorbidities and exercise adherence is a challenge beyond personal physiotherapy. The main objective of this study is to investigate the short- and long-term (cost-)effectiveness of the SmArt-E programme in people with hip and/or knee osteoarthritis in terms of pain and physical functioning compared to usual care. Methods This study is designed as a multicentre randomized controlled trial with a target sample size of 330 patients. The intervention is based on the e-Exercise intervention from the Netherlands, consists of a training and education programme and is conducted as a blended care intervention over 12 months. We use an app to support independent training and the development of self-management skills. The primary and secondary hypotheses are that participants in the SmArt-E intervention will have less pain (numerical rating scale) and better physical functioning (Hip Disability and Osteoarthritis Outcome Score, Knee Injury and Osteoarthritis Outcome Score) compared to participants in the usual care group after 12 and 3 months. Other secondary outcomes are based on domains of the Osteoarthritis Research Society International (OARSI). The study will be accompanied by a process evaluation. Discussion After a positive evaluation, SmArt-E can be offered in usual care, flexibly addressing different care situations. The desired sustainability and the support of the participants’ behavioural change are initiated via the app through audio-visual contact with their physiotherapists. Furthermore, the app supports the repetition and consolidation of learned training and educational content. For people with osteoarthritis, the new form of care with proven effectiveness can lead to a reduction in underuse and misuse of care as well as contribute to a reduction in (in)direct costs. Trial registration German Clinical Trials Register, DRKS00028477. Registered on August 10, 2022. KW - Telerehabilitation KW - Osteoarthritis KW - Physical therapy modalities KW - Exercise therapy KW - Education KW - Combined modality therapy Y1 - 2023 UR - https://bmcmusculoskeletdisord.biomedcentral.com/articles/10.1186/s12891-023-06255-7 U6 - http://dx.doi.org/10.1186/s12891-023-06255-7 IS - 24 SP - 1 EP - 23 ER - TY - GEN A1 - Smyth, Siobhan A1 - Finn, Yvonne A1 - Dütthorn, Nadin A1 - Groddeck, Luisa A1 - Jordan, F. T1 - Innovative Virtual Reality Simulation Scenarios for Final Year Undergraduate Nursing Education Programmes [Oral presentation], KN Cheung SK Chin InterSim Inaugural Conference, Queens University, Belfast. 9th of June Y1 - 2023 ER - TY - JOUR A1 - Thiele, Uwe A1 - Snoeijer, Jacco A1 - Trinschek, Sarah A1 - John, Karin T1 - Equilibrium contact angle and adsorption layer properties with surfactants JF - Langmuir Y1 - 2018 U6 - http://dx.doi.org/10.1021/acs.langmuir.8b00513 VL - 34 IS - 24 SP - 7210 EP - 7221 ER - TY - JOUR A1 - Feroz, Hasin A1 - Ferlez, Bryan A1 - Oh, Hyeonji A1 - Mohammadiarani, Hossein A1 - Ren, Tingwei A1 - Baker, Carol S. A1 - Gajewski, John P. A1 - Lugar, Daniel J. A1 - Gaudana, Sandeep B. A1 - Butler, Peter A1 - Hühn, Jonas A1 - Lamping, Matthias A1 - Parak, Wolfgang J. A1 - Blatt, Michael R. A1 - Kerfeld, Cheryl A. A1 - Smirnoff, Nicholas A1 - Vashisth, Harish A1 - Golbeck, John H. A1 - Kumar, Manish T1 - Liposome-based measurement of light-driven chloride transport kinetics of halorhodopsin JF - Liposome-based measurement of light-driven chloride transport kinetics of halorhodopsin Y1 - 2021 U6 - http://dx.doi.org/10.1016/j.bbamem.2021.183637 SN - 0005-2736 VL - 1863 IS - 8 SP - 183637 ER - TY - JOUR A1 - Lamping, Matthias A1 - Enck, Sebastian A1 - Geyer, Armin T1 - Inverse γ-Turn-Inspired Peptide: Synthesis and Analysis of Segetalin A Indole Hemiaminal JF - European Journal of Organic Chemistry N2 - Substitution of a peptide bond for an imine transforms the irreversible macrocyclization of peptides into a reversible process. The inherent cyclization tendency of a linear peptide is then analyzable through the equilibrium between the aldehyde and the imine by virtue of the higher reactivity of the corresponding linear peptide aldehyde. The tryptophan side chain of segetalin A aldehyde forms a 12‐membered cyclic indole hemiaminal instead of the 18‐membered macrocyclic imine expected. Herein, we analyzed this uncommon hemiaminal that shows that the biosynthesis of cyclic peptides is not necessarily based on linear precursor peptides with a high inherent macrolactamization tendency. KW - Peptides KW - Aldehydes KW - Cyclization KW - Macrocycles KW - Nitrogen heterocycles Y1 - 2015 U6 - http://dx.doi.org/10.1002/ejoc.201501179 SN - 1099-0690 VL - 2015 IS - 34 SP - 7443 EP - 7448 ER - TY - JOUR A1 - Lamping, Matthias A1 - Grell, Yvonne A1 - Geyer, Armin T1 - Synthesis and conformational analysis of an expanded cyclic ketoxime-hexapeptide JF - Journal of Peptide Science N2 - n this work the synthesis of a linear hexapeptide with a hydroxylamine functionality at the N‐terminus and a ketone instead of the carboxylic acid at the C‐terminus is described. Cyclization by ketoxime formation yields the 19‐membered ring‐expanded cyclic hexapeptide cyclo[Goly‐Val‐Ala‐Pro‐Leu‐Kly] which adopts a main conformer with two intramolecular hydrogen bonds. The hydrolytic stability of a ketoxime lies between the inert amide and the labile imine. The substitution of an amide bond for an iminium bond transforms the irreversible macrocyclization into a reversible process, but macrocyclic imines are difficult to isolate because they are prone to hydrolysis. The enhanced chemical stability of the ketoxime justifies its application in ligation protocols. The detailed NMR analysis of a ketoxime linkage presented here identifies its local conformational preferences in a constrained peptide environment. KW - Peptide KW - Cyclization KW - NMR KW - Oxime KW - Conformation Y1 - 2016 U6 - http://dx.doi.org/10.1002/psc.2873 SN - 1099-1387 VL - 22 IS - 4 SP - 228 EP - 235 ER - TY - JOUR A1 - Fischer, Sabrina A1 - Lamping, Matthias A1 - Gold, Maike A1 - Röttger, Yvonne A1 - Brödje, Dörte A1 - Dodel, Richard A1 - Frantz, Renate A1 - Mraheil, Mobarak Abu A1 - Chakraborty, Trinad A1 - Geyer, Armin T1 - Synthesis of a biological active β-hairpin peptide by addition of two structural motifs JF - Bioorganic & Medicinal Chemistry N2 - The idea of privileged scaffolds – that there seem to be more bioactive compounds found around some structures than others – is well established for small drug molecules, but has little significance for standalone peptide secondary structures whose adaptable shapes escape the definition of a 3D motif in the absence of a protein scaffold. Here, we joined two independent biological functions in a single highly restricted peptide to support the hypothesis that the β-hairpin shape is the common basis of two otherwise unrelated biological recognition processes. To achieve this, the hydrophobic cluster HWX4LV from the decapeptide cyclic hairpin model peptide C1-C10 cyclo-CHWEGNKLVC was included in the bicyclic peptide 2. The designed β-hairpin peptide C4-C17, C8-C13 bicyclo-KHQCHWECTZGRCRLVCGRSGS (2, Z = citrulline), serves, on the one hand, as a specific epitope for rheumatoid autoantibodies and, on the other hand, shows a not negligible antibiotic effect against the bacterial strain E. coli AS19. KW - Peptides KW - Disulfides KW - NMR spectroscopy KW - Filaggrin Y1 - 2017 U6 - http://dx.doi.org/10.1016/j.bmc.2016.11.022 SN - 0968-0896 VL - 25 IS - 2 SP - 603 EP - 608 ER - TY - JOUR A1 - Feroz, Hasin A1 - Ferlez, Bryan A1 - Lefoulon, Cecile A1 - Ren, Tingwei A1 - Baker, Carol S. A1 - Gajewski, John P. A1 - Lugar, Daniel J. A1 - Gaudana, Sandeep B. A1 - Butler, Peter J. A1 - Hühn, Jonas A1 - Lamping, Matthias A1 - Parak, Wolfgang J. A1 - Hibberd, Julian M. A1 - Kerfeld, Cheryl A. A1 - Smirnoff, Nicholas A1 - Blatt, Michael R. A1 - Golbeck, John H. A1 - Kumar, Manish T1 - Light-Driven Chloride Transport Kinetics of Halorhodopsin JF - Biophysical Journal N2 - Despite growing interest in light-driven ion pumps for use in optogenetics, current estimates of their transport rates span two orders of magnitude due to challenges in measuring slow transport processes and determining protein concentration and/or orientation in membranes in vitro. In this study, we report, to our knowledge, the first direct quantitative measurement of light-driven Cl− transport rates of the anion pump halorohodopsin from Natronomonas pharaonis (NpHR). We used light-interfaced voltage clamp measurements on NpHR-expressing oocytes to obtain a transport rate of 219 (± 98) Cl−/protein/s for a photon flux of 630 photons/protein/s. The measurement is consistent with the literature-reported quantum efficiency of ∼30% for NpHR, i.e., 0.3 isomerizations per photon absorbed. To reconcile our measurements with an earlier-reported 20 ms rate-limiting step, or 35 turnovers/protein/s, we conducted, to our knowledge, novel consecutive single-turnover flash experiments that demonstrate that under continuous illumination, NpHR bypasses this step in the photocycle. KW - Optogenetics Y1 - 2018 UR - https://www.cell.com/biophysj/fulltext/S0006-3495(18)30685-4 U6 - http://dx.doi.org/10.1016/j.bpj.2018.06.009 SN - 1542-0086 VL - 115 IS - 2 SP - 353 EP - 360 ER - TY - BOOK A1 - Schneider, Peter A1 - Kohmäscher, Anke T1 - My child stutters – what can I do? Y1 - 2017 SN - 9783936640328 PB - Natke CY - Neuss ER - TY - JOUR A1 - Alpermann, Anke A1 - Huber, Walter A1 - Natke, Ulrich A1 - Willmes-van Hinckeldey, Klaus T1 - Construct validity of modified time-interval analysis in measuring stuttering and trained speech patterns JF - Journal of Fluency Disorders Y1 - 2012 U6 - http://dx.doi.org/10.1016/j.jfludis.2011.11.006 VL - 37 IS - 1 SP - 42 EP - 53 ER - TY - GEN A1 - Ungru, Kathrin T1 - Dynamic Programming Based Segmentation in Biomedical Imaging, eingeladener Vortrag, 3.3.2017, Universidade Federal do Rio Grande do Norte (UFRN), Natal, Brasilien Y1 - 2017 ER - TY - JOUR A1 - Ungru, Kathrin A1 - Jiang, Xiaoyi ED - Elsevier, T1 - Dynamic Programming Based Segmentation in Biomedical Imaging. JF - Computational and Structural Biotechnology Journal Y1 - 2017 U6 - http://dx.doi.org/10.1016/j.csbj.2017.02.001 VL - 15 SP - 255 EP - 264 ER - TY - CHAP A1 - Tenbrinck, Daniel A1 - Ungru, Kathrin A1 - Jiang, Xiaoyi A1 - Stypmann, Jörg T1 - Regional Classification of Left Ventricular Wall in Small Animal Ultrasound Imaging. T2 - ACBIT 2013 Y1 - 2014 SN - 978-3-642-54121-6 U6 - http://dx.doi.org/10.1007/978-3-642-54121-6_21 SP - 248 EP - 256 PB - Springer CY - Berlin, Heidelberg ER -