@misc{HusainHillmannHengstetal.2023, author = {Husain, Sarah and Hillmann, Katharina and Hengst, Karin and Englert, Heike}, title = {Effects of a lifestyle intervention on the biomarkers of oxidative stress in non-communicable diseases: A systematic review}, series = {Frontiers in Aging}, journal = {Frontiers in Aging}, publisher = {Frontiers Journal}, address = {Germany}, doi = {10.25974/fhms-16082}, url = {http://nbn-resolving.de/urn:nbn:de:hbz:836-opus-160827}, year = {2023}, abstract = {Oxidative stress plays a critical role in the pathogenesis of chronic diseases. Therefore, improvement of oxidative stress status through lifestyle intervention can play a vital role in preventing and treating chronic diseases. This systematic review aims to provide an overview of articles published in the last decade examining the association between lifestyle intervention and oxidative stress biomarkers in the context of non-communicable diseases. The electronic databases PubMed and Web of Science were searched for relevant studies, following the PRISMA (Preferred Reporting of Systematic Reviews and Meta-Analyses) guidelines. This systematic review focused on the four important oxidative stress biomarkers; glutathione (GSH), superoxide dismutase (SOD), catalase, and malondialdehyde. 671 articles were identified, of which nine met the inclusion criteria. A trend emerged, showing that lifestyle modifications that focus on diet and physical health can improve oxidative stress in the form of an increase in superoxide dismutase and CAT levels and a decrease in Malondialdehyde levels in participants with non-communicable diseases (NCDs), GSH levels were not affected. However, the results are difficult to compare because of the heterogeneity of the methods of the biomarkers studied. Our review indicates that oxidative stress can be influenced by lifestyle modifications and may be an effective tool for the prevention and management of non-communicable diseases. This review also elucidated the importance of analyzing multiple oxidative stress biomarkers to evaluate oxidative stress, it further highlights the need to conduct long-term lifestyle intervention studies on oxidative stress biomarkers to understand the connection between oxidative stress biomarkers, NCDs and Lifestyle intervention.}, language = {en} } @article{BlumentrittLuigEnklaaretal.2023, author = {Blumentritt, Sebastian and Luig, Theresa and Enklaar, Arnold and Englert, Heike}, title = {Betriebliche Gesundheitsf{\"o}rderung (BGF) im Laufe der Zeit}, doi = {10.25974/fhms-18056}, url = {http://nbn-resolving.de/urn:nbn:de:hbz:836-opus-180562}, year = {2023}, abstract = {Hintergrund.ZurQualit{\"a}tssicherungund WeiterentwicklungvonBGF-Maßnahmen (betrieblicheGesundheitsf{\"o}rderung) istes vonInteresse,einen{\"U}berblick{\"u}berwissen schaftlichuntersuchteBGF-Maßnahmenin denletztenzweiJahrzehntenzuerlangen. Zielsetzung.WissenschaftlichevaluierteBGF MaßnahmenausdenJahren2000-2020wer denmithilfederinderPraxisdurchdenGKV SpitzenverbandeingesetztenThemenfelder aufdiethematischenEntwicklungen,den Nutzen,aberauchdieSchw{\"a}chenf{\"u}rdie {\"U}bertragbarkeitindiePraxishinanalysiert. Methode.EinesystematischeLiteraturrecher chef{\"u}rdenPublikationszeitraumzwischen 2000und2020wurdeinzweielektronischen Datenbankendurchgef{\"u}hrt. Ergebnisse.DieEinschlusskriterienerf{\"u}llten 41Artikel.DiemeistenderindenStudien durchgef{\"u}hrtenundevaluiertenBGF MaßnahmenwarenkeineEinzelmaßnahmen, sondernstelltenProgrammedar. Inihnen wurdenmehrereThemenfeldergleichzeitig adressiert.Insgesamtzeigtensichdieinden StudienuntersuchtenBGF-Maßnahmensehr heterogen.ZumEndedesUntersuchungszeit raumesnahmdieAnzahlanPublikationen zu. Schlussfolgerung.DieimLeitfadenPr{\"a}venti onvorgegebenenBGF-Themenfeldersindbis aufeinThemenfeldausgewogenvertreten. DieStudienzudenBGF-Maßnahmen sindbezogenaufdieVerst{\"a}ndlichkeitder angewendetenDidaktikundMethodikoft nureingeschr{\"a}nktnachvollziehbarund somitschwerindieorganisationalePraxis {\"u}bertragbar.}, language = {de} } @article{BlumentrittLuigEnklaaretal.2023, author = {Blumentritt, Sebastian and Luig, Teresa and Enklaar, Arnold and Englert, Heike}, title = {Ist-Analysen, Theorien und Effekte in evaluierten Interventionen der betrieblichen Gesundheitsf{\"o}rderung (BGF) Ein Literatur-Review f{\"u}r den Zeitraum 2000 bis 2020}, doi = {10.25974/fhms-18054}, url = {http://nbn-resolving.de/urn:nbn:de:hbz:836-opus-180545}, year = {2023}, abstract = {Zusammenfassung Hintergrund. Zur qualit{\"a}tsbasierten Weiterentwicklungeffizienter und bedarfs orientierter Maßnahmen der betrieblichen Gesundheitsf{\"o}rderung (BGF) ist es von Interesse, einen Einblick in Ihren Aufbau, die Ausgestaltung und den Ablauf der Maßnahmender letztenzwei Jahrzehntezu erlangen. Zielsetzung. Auf Basis der arbeitsschutzori entierten Leitliniendes GKV-Spitzenverbands wird untersucht, ob vor der Umsetzung von BGF-Maßnahmen Bedarfserhebungen mittels Ist-Analysen durchgef{\"u}hrt wurden. Zus{\"a}tzlich wird betrachtet,ob die Analysen „weiche" Faktoren wie Kultur, F{\"u}hrung und Beziehungsklima beinhalten. Weiter wird analysiert, welche wissenschaftlichenTheori en undModelle denMaßnahmenzugrunde liegen. Zudem f{\"u}hrt die Untersuchungeine Wirksamkeitsbetrachtungdurch, um zu ermitteln, welche Effekte die Maßnahmen erzielten. Methode. Das vorliegende Literatur-Review untersucht wissenschaftlichevaluierte BGF Maßnahmenaus den Jahren 2000-2020. Hierzu wurde eine systematischeLitera turrecherche in den zwei elektronischen DatenbankenScopus und Web of Science f{\"u}r den benannten Publikationszeitraum durchgef{\"u}hrt. Ergebnisse. Die Einschlusskriterienerf{\"u}llten 41Artikel.Nur4derStudienf{\"u}hrteneine Ist-Analyse zur Bedarfsbestimmung von BGF-Maßnahmendurch. 25 Studien f{\"u}hrten Ist-Analysen im Rahmen der Maßnahmen durch, alle waren arbeitsschutzorientiert.Vier Studien inkludierten in ihrer Erhebung zu Beginn Teilaspektevon weichen Faktoren. In 12 Studienwurdenden evaluiertenInterven tionen unterschiedliche wissenschaftliche Theorien und Modelle zugrunde gelegt. Alle Studien berichtetenmindestensf{\"u}r einzelne Untersuchungsparametervon positiven Effekten. Schlussfolgerung. Vor dem Hintergrund des Strukturwandels der Wirtschaft und der best{\"a}ndig zunehmenden Humanisierung der Arbeit spielen wissenschaftsbasierte Analyseinstrumentezur Bedarfsbestimmung eine große Rolle. Zuk{\"u}nftige Analyseinstru mentesolltenvon derWissenschaftkonzipiert und erprobt werden und zus{\"a}tzlich zur Arbeitsschutzorientierung die immateriellen, weichen Faktoren Kultur, F{\"u}hrung und Beziehungsklima beinhalten. Trotz der Empfehlungen, Maßnahmenauf Grundlage von Theorien und Modellen zu konzipieren, wurde dieses Potenzial von nur wenigen wissenschaftlichevaluiertenStudien genutzt. Die Wirksamkeitsbetrachtungzeigt, dass alle Studien mindestensf{\"u}r Teile Ihrer Evaluation von positiven Effekten berichten. Dieses Untersuchungsergebnisdes Reviewsweist auf ein Publikationsbiashin}, language = {de} } @article{KoederAnandHusainetal.2023, author = {Koeder, Christian and Anand, Corinna and Husain, Sarah and Kranz, Ragna-Marie and Schoch, Nora and Alzughayyar, Dima and Bitterlich, Norman and Hahn, Andreas and Englert, Heike}, title = {Exploratory analysis of the effect of a controlled lifestyle intervention on inflammatory markers - the Healthy Lifestyle Community Programme (cohort 2)}, series = {BMC Nutrition}, volume = {9}, journal = {BMC Nutrition}, number = {25}, issn = {2055-0928}, doi = {10.1186/s40795-023-00684-2}, year = {2023}, abstract = {Background Chronic low-grade inflammation is associated with an increased risk of chronic disease and mortality. The objective of the study was to test the effect of a healthy lifestyle intervention on biomarkers of inflammation (among other risk markers). Methods We conducted a non-randomized controlled trial with mostly middle-aged and elderly participants from the general population in rural northwest Germany (intervention: n = 114; control: n = 87). The intervention consisted of a 1-year lifestyle programme focusing on diet (largely plant-based; strongest emphasis), physical activity, stress management, and social support. High-sensitivity C-reactive protein (hs-CRP) was assessed at baseline, 10 weeks, 6 months, and 1 year. Homocysteine (Hcy) was assessed at baseline, 10 weeks, and 1 year. Adiponectin (Apn) was assessed at baseline and 10 weeks. An exploratory analysis of these inflammatory markers assessing the between-group differences with ANCOVA was conducted. Results The 1-year trajectory of hs-CRP was significantly lower in the intervention group compared to control (between-group difference: -0.8 (95\% CI -1.2, -0.3) mg/l; p = 0.001; adjusted for baseline). The 1-year trajectory of Hcy was non-significantly higher in the intervention compared to control (between-group difference: 0.2 (95\% CI -0.3, 0.7) µmol/l; p = 0.439; adjusted for baseline). From baseline to 10 weeks, Apn decreased significantly more in the intervention group compared to control (between-group difference: -1.6 (95\% CI -2.7, -0.5) µg/ml; p = 0.004; adjusted for baseline). Conclusions Our study shows that healthy lifestyle changes can lower hs-CRP and Apn levels and are unlikely to significantly affect Hcy levels within 1 year. Trial registration German Clinical Trials Register (DRKS; reference: DRKS00018775, registered 12 Sept 2019; retrospectively registered; www.drks.de).}, language = {en} } @article{KranzKettlerAnandetal.2023, author = {Kranz, Ragna-Marie and Kettler, Carmen and Anand, Corinna and Koeder, Christian and Husain, Sarah and Schoch, Nora and Buyken, Anette and Englert, Heike}, title = {Effect of a controlled lifestyle intervention on medication use and costs: The Healthy Lifestyle Community Program (cohort 2)}, series = {Nutrition and Health}, journal = {Nutrition and Health}, publisher = {Sage Publications}, issn = {2047-945X}, doi = {10.25974/fhms-16217}, url = {http://nbn-resolving.de/urn:nbn:de:hbz:836-opus-162176}, year = {2023}, abstract = {Background: Establishing a healthy lifestyle has a great potential to reduce the prevalence of non-communicable diseases (NCDs) and their risk factors. NCDs contribute immensely to the economic costs of the health care system arising from therapy, medication use, and productivity loss. Aim: The aim of this study was to evaluate the effect of the Healthy Lifestyle Community Program (cohort 2; HLCP-2) on medication use and consequently on medication costs for selected NCDs (diabetes, hypertension, and dyslipidemia). Methods: Data stem from a 24-month non-randomised, controlled intervention trial aiming to improve risk factors for NCDs. Participants completed questionnaires at six measurement time points assessing medication use, from which costs were calculated. The following medication groups were included in the analysis as NCD medication: glucose-lowering medications (GLM), antihypertensive drugs (AHD) and lipid-lowering drugs (LLD). Statistical tests for inter- and intra-group comparison and multiple regression analysis were performed. Results: In total, 118 participants (intervention group [IG]: n = 79; control group [CG]: n = 39) were considered. Compared to baseline medication use decreased slightly in the IG and increased in the CG. Costs for NCD medication were significantly lower in the IG than in the CG after 6 (p = 0.004), 12 (p = 0.040), 18 (p = 0.003) and 24 months (p = 0.008). After multiple regression analysis and adjusting for confounders, change of costs differed significantly between the groups in all final models. Conclusion: The HLCP-2 was able to moderately prevent an increase of medication use and thus reduce costs for medication to treat NCDs with the greatest impact on AHD.}, language = {de} } @article{KranzKettlerKoederetal.2023, author = {Kranz, Ragna-Marie and Kettler, Carmen and Koeder, Christian and Husain, Sarah and Anand, Corinna and Schoch, Nora and Englert, Heike}, title = {Health Economic Evaluation of a Controlled Lifestyle Intervention: The Healthy Lifestyle Community Program (Cohort 2; HLCP-2)}, series = {Nutrients}, journal = {Nutrients}, doi = {10.25974/fhms-17454}, url = {http://nbn-resolving.de/urn:nbn:de:hbz:836-opus-174544}, year = {2023}, abstract = {Non-communicable diseases (NCD) are associated with high costs for healthcare systems. We evaluated changes in total costs, comprising direct and indirect costs, due to a 24-month non-randomized, controlled lifestyle intervention trial with six measurement time points aiming to improve the risk profile for NCDs. Overall, 187 individuals from the general population aged ≥18 years were assigned to either the intervention group (IG; n = 112), receiving a 10-week intensive lifestyle intervention focusing on a healthy, plant-based diet; physical activity; stress management; and community support, followed by a 22-month follow-up phase including monthly seminars, or a control group (CG; n = 75) without intervention. The complete data sets of 118 participants (IG: n = 79; CG: n = 39) were analyzed. At baseline, total costs per person amounted to 67.80 ± 69.17 EUR in the IG and 48.73 ± 54.41 EUR in the CG per week. The reduction in total costs was significantly greater in the IG compared to the CG after 10 weeks (p = 0.012) and 6 months (p = 0.004), whereas direct costs differed significantly after 10 weeks (p = 0.017), 6 months (p = 0.041) and 12 months (p = 0.012) between the groups. The HLCP-2 was able to reduce health-related economic costs, primarily due to the reduction in direct costs.}, language = {en} } @article{AnandHengstGellneretal.2023, author = {Anand, Corinna and Hengst, Karin and Gellner, Reinhold and Englert, Heike}, title = {Effects of the healthy lifestyle community program (cohort 1) on stress-eating and weight change after 8 weeks: a controlled study}, series = {Scientific Reports}, volume = {13}, journal = {Scientific Reports}, doi = {10.1038/s41598-022-27063-4}, pages = {1 -- 12}, year = {2023}, abstract = {Stress-eating (eating more or more unhealthily in order to accommodate to stress), contributes to the development and maintenance of obesity. The effect of comprehensive weight loss interventions on changes in stress-eating as well as the contributing role of stress-eating on weight reduction has not been examined. The impact of the 8-week intensive phase of the Healthy Lifestyle Community Programme (HLCP, cohort 1) on emotional, external and restrained eating, as expressions of stress-eating was evaluated in a non-randomized controlled trial. Intervention: 14 seminars (twice per week, including practical units), complemented by stress-regulation and cooking workshops and coaching sessions empowering participants to change their behaviour towards a healthy plant-based diet (ad libitum), stress regulation, regular exercise and to focus on social support. Participants were recruited from the general population. In the intervention group, 91 participants (IG; age: 56 ± 10, 77\% female) and in the control group, 52 (CG; age: 62 ± 14, 57\% female) were enrolled. At baseline, participants of the IG reported higher levels of stress (9.7 ± 5.4 points [P] vs. 7.6 ± 6.2; p < 0.011), and of emotional eating (27.9 ± 9.4 vs. 20.0 ± 7.1; p < 0.001) and external eating (29.1 ± 4.9 vs. 25.5 ± 5.6; p < 0.001) than participants of the CG. Within 8 weeks, in the IG, scores of emotional eating (- 3.5 ± 5.4 P) and external eating significantly decreased (= - 2.0 ± 3.8 P), while restrained eating increased (2.7 ± 5.0 P; p for all < 0.001). Weight change was negatively correlated with change of external eating (R2 = 0.045; CC = - 0.285; p = 0.014), indicating that a greater weight change was associated with a smaller change of external eating. This is the first study to prospectively investigate the role of stress-eating on the weight reduction effect of comprehensive lifestyle interventions. Our data confirm that overweight is associated with EE and external eating and suggest that the HLCP is capable to reduce both, weight and stress-eating.}, language = {en} } @techreport{EnglertAnandSchochetal.2023, author = {Englert, Heike and Anand, Corinna and Schoch, Nora and Blumentritt, Sebastian}, title = {Handlungsleitfaden "health.pro.fit:Polizei" f{\"u}r ganzheitliches Beh{\"o}rdliches Gesundheitsmanagement und wirksame Gesundheitsforderung in Polizeibeh{\"o}rden}, year = {2023}, language = {de} }