@inproceedings{KranzEnglert2020,
  author    = {Kranz, Ragna-Marie and Englert, Heike},
  title     = {Potenzial eines Community-basierten Lebensstilprogramms zur Pr{\"a}vention von Diabetes mellitus Typ 2 im gesundheits{\"o}konomischen Kontext},
  series = {Proceedings of the German Nutrition Society},
  booktitle = {Proceedings of the German Nutrition Society},
  isbn      = {978-3-88749-267-0},
  pages     = {73},
  year      = {2020},
  abstract  = {Hintergrund: Der globale Anstieg von lebensstilabhängigen Erkrankungen, wie Diabetes mellitus Typ 2 (DMT2), f{\"u}hrt zu enormen Belastungen f{\"u}r das Gesundheitssystem. Dabei er-weist sich insbesondere der DMT2 häufig durch regelmäßige Untersuchungen und Medikationen als sehr kostenintensiv. Vor diesem Hintergrund stellt sich die Frage, inwiefern ein Le-bensstilprogramm (LSP), durch die Senkung der N{\"u}chternglu-cose und des HbA1c-Wertes, das DM2T-Risikoprofil verbessern und dem {\"U}bergang des Prädiabetes in einen DMT2 entgegen-wirken sowie sukzessive Kosteneinsparungen erzielen kann.Methoden: Das LSP umfasst eine 24-monatige, prospektive und kontrollierte Interventionsstudie mit Personen ≥18Jah-ren. Datenerhebungen wurden zur Baseline (t0) sowie nach 10 Wochen (t1) und 6, 12, 18 und 24 Monaten (t2-t5) festge-legt. Dabei werden u.a. Laborparameter (z.B. N{\"u}chternglu-cose und HbA1c) sowie gesundheits{\"o}konomische Parameter (z.B. Behandlungen und Medikationen) erfasst. In der Inter-ventionsgruppe (N=112) wurden individuelle Coachings, ein 10-w{\"o}chiges intensives LSP und monatliche Folgetreffen durchgef{\"u}hrt. Die Kontrollgruppe (N=87) erhielt ein „Treat-ment as usual".Ergebnisse: In der Interventionsgruppe zeigte sich eine kon-tinuierliche Verringerung der N{\"u}chternglucose (p<0,05), bis-her jedoch keine signifikante HbA1c-Reduktion, innerhalb der ersten 3 Messzeitpunkte (t0-t2). In der Kontrollgruppe wurde eine geringere Senkung der N{\"u}chternglucose (p<0,01) sowie ein leichter Anstieg des HbA1c-Wertes (p<0,01) beobachtet (t0-t2).Schlussfolgerung: Das LSP konnte bisher zu einer Verbes-serung des DMT2-Risikoprofils f{\"u}hren (t0-t2) und kann sich präventiv auf die Manifestation und den {\"U}bergang eines Prä-diabetes in einen DMT2 auswirken. Daraus k{\"o}nnen Kosten-einsparungen abgeleitet werden. Die Auswertung weiterer Messzeitpunkte kann die langfristigen Auswirkungen des LSPs auf die Verbesserung von DMT2-assoziierten Parametern und damit verbundenen gesundheits{\"o}konomischen Parame-tern aufzeigen.},
  language  = {de}
}
@article{KranzEnglert2021,
  author    = {Kranz, Ragna-Marie and Englert, Heike},
  title     = {Effect of a community-based lifestyle intervention programme on quality of life among German women},
  series = {European Journal of Public Health},
  volume    = {Volume 31},
  journal   = {European Journal of Public Health},
  doi       = {10.1093/eurpub/ckab165.389},
  year      = {2021},
  abstract  = {Background Quality of life is an important concept in the field of health, which can be influenced by various lifestyle factors. The objective was to test if a community-based lifestyle programme would beneficially affect the health-related quality of life of German women. Methods The controlled intervention study had a total duration of 24 months. Quality of life (EQ-5D-3L), anthropometrics, vital and blood parameters as well as diagnosed diseases and health economic parameters were collected at baseline (t0), after 10 weeks (t1) and after 6 months (t2). For the intervention group (n = 65) a 10-week intensive lifestyle programme followed by monthly alumni meetings were conducted. The intensive phase consisted of 14 consecutive seminars about a healthy lifestyle, which focused on a plant-based diet, physical activity, stress management and community support. The control group (n = 35) received no intervention. Results The first descriptive health profile results of the subgroup analysis showed that 59\% women of the intervention group at t0 (t1: 37\%; t2: 48\%) and 60\% of the control group at t0 (t1: 54\%; t2: 49\%) reported problems in at least one of the EQ-5D dimensions (mobility, selfcare, activities, pain, and anxiety). A significant difference in EQ VAS change between women in intervention (7,15 [95\% CI 4,32; 9,98]; EQ VAS t0: 75,35 [SD 13,71]) and control group (-2,63 [95\% CI -5,40; 0,15]; EQ VAS t0: 78,80 [SD 18,51]) from t0 to t1 was observed (p < 001; adjusted for baseline). No significant differences in mean EQ VAS change from t0 to t2 and in mean EQ-5D index change from t0 to t1 and t0 to t2 between the groups were observed (p > 0,05; adjusted for baseline). Conclusions The preliminary results suggest that the lifestyle intervention programme can have a positive short-time effect on some aspects of quality of life, such as the health profile and EQ VAS. However, the long-term results will be shown in the future. Key messages - A healthy lifestyle can affect the quality of life in a positive way. - The community-based lifestyle programme had a short-time influence on the descriptive health profile and EQ VAS of German women, whereby the EQ index didńt change significantly between the groups.},
  language  = {en}
}
@article{KranzKettlerAnandetal.2023,
  author    = {Kranz, Ragna-Marie and Kettler, Carmen and Anand, Corinna and Koeder, Christian and Husain, Sarah and Schoch, Nora and Buyken, Anette and Englert, Heike},
  title     = {Effect of a controlled lifestyle intervention on medication use and costs: The Healthy Lifestyle Community Program (cohort 2)},
  series = {Nutrition and Health},
  journal   = {Nutrition and Health},
  publisher = {Sage Publications},
  issn      = {2047-945X},
  doi       = {10.25974/fhms-16217},
  url       = {http://nbn-resolving.de/urn:nbn:de:hbz:836-opus-162176},
  year      = {2023},
  abstract  = {Background: Establishing a healthy lifestyle has a great potential to reduce the prevalence of non-communicable diseases (NCDs) and their risk factors. NCDs contribute immensely to the economic costs of the health care system arising from therapy, medication use, and productivity loss. Aim: The aim of this study was to evaluate the effect of the Healthy Lifestyle Community Program (cohort 2; HLCP-2) on medication use and consequently on medication costs for selected NCDs (diabetes, hypertension, and dyslipidemia). Methods: Data stem from a 24-month non-randomised, controlled intervention trial aiming to improve risk factors for NCDs. Participants completed questionnaires at six measurement time points assessing medication use, from which costs were calculated. The following medication groups were included in the analysis as NCD medication: glucose-lowering medications (GLM), antihypertensive drugs (AHD) and lipid-lowering drugs (LLD). Statistical tests for inter- and intra-group comparison and multiple regression analysis were performed. Results: In total, 118 participants (intervention group [IG]: n = 79; control group [CG]: n = 39) were considered. Compared to baseline medication use decreased slightly in the IG and increased in the CG. Costs for NCD medication were significantly lower in the IG than in the CG after 6 (p = 0.004), 12 (p = 0.040), 18 (p = 0.003) and 24 months (p = 0.008). After multiple regression analysis and adjusting for confounders, change of costs differed significantly between the groups in all final models. Conclusion: The HLCP-2 was able to moderately prevent an increase of medication use and thus reduce costs for medication to treat NCDs with the greatest impact on AHD.},
  language  = {de}
}
@article{KranzKettlerKoederetal.2023,
  author    = {Kranz, Ragna-Marie and Kettler, Carmen and Koeder, Christian and Husain, Sarah and Anand, Corinna and Schoch, Nora and Englert, Heike},
  title     = {Health Economic Evaluation of a Controlled Lifestyle Intervention: The Healthy Lifestyle Community Program (Cohort 2; HLCP-2)},
  series = {Nutrients},
  journal   = {Nutrients},
  doi       = {10.25974/fhms-17454},
  url       = {http://nbn-resolving.de/urn:nbn:de:hbz:836-opus-174544},
  year      = {2023},
  abstract  = {Non-communicable diseases (NCD) are associated with high costs for healthcare systems. We evaluated changes in total costs, comprising direct and indirect costs, due to a 24-month non-randomized, controlled lifestyle intervention trial with six measurement time points aiming to improve the risk profile for NCDs. Overall, 187 individuals from the general population aged ≥18 years were assigned to either the intervention group (IG; n = 112), receiving a 10-week intensive lifestyle intervention focusing on a healthy, plant-based diet; physical activity; stress management; and community support, followed by a 22-month follow-up phase including monthly seminars, or a control group (CG; n = 75) without intervention. The complete data sets of 118 participants (IG: n = 79; CG: n = 39) were analyzed. At baseline, total costs per person amounted to 67.80 ± 69.17 EUR in the IG and 48.73 ± 54.41 EUR in the CG per week. The reduction in total costs was significantly greater in the IG compared to the CG after 10 weeks (p = 0.012) and 6 months (p = 0.004), whereas direct costs differed significantly after 10 weeks (p = 0.017), 6 months (p = 0.041) and 12 months (p = 0.012) between the groups. The HLCP-2 was able to reduce health-related economic costs, primarily due to the reduction in direct costs.},
  language  = {en}
}