@article{WinterMuellerBrandesetal.2009, author = {Winter, Corinna and M{\"u}ller, Carsten and Brandes, Mirko and Brinkmann, Anja and Hoffmann, Christiane and Hardes, Jendrik and Gosheger, Georg and Boos, Joachim and Rosenbaum, Dieter}, title = {Level of activity in children undergoing cancer treatment}, series = {Pediatric Blood \& Cancer}, volume = {53}, journal = {Pediatric Blood \& Cancer}, number = {3}, doi = {10.1002/pbc.22055}, pages = {438 -- 443}, year = {2009}, abstract = {Background The diagnosis of cancer bears severe implications for pediatric patients. One immense restriction consists in a reduced level of activity due to different factors. Physical activity affects various aspects of development and can be regarded as an essential part of a child's life. In the present study physical activity in patients undergoing cancer therapy was quantified in order to determine the extent of the restriction and to provide baseline information for the assessment of possible interventions. Procedure Physical activity in 80 patients and 45 healthy children matched for age and gender was measured using the StepWatch 3™ Activity Monitor (SAM, OrthoCare Innovations). Results Pediatric cancer patients, at 2,787 gait cycles (gcs) per day, were significantly less active than their healthy counterparts (8,096 gcs). Patients were significantly more active at home than during inpatient stays (3,185 gcs compared to 1,830 gcs), and patients with bone tumors were less active than those with leukemia regarding both, the amount (1,849 gcs vs. 2,992 gcs) and the intensity of activity. Conclusion The present study quantified an often observed but so far hardly assessable problem. Activity in cancer patients is considerably reduced and patients with bone tumors are at increased risk from the detrimental effects of prolonged inactivity. Both our findings and the accepted fact that activity is an essential element of child development confirm the need for interventions tailored to a patient's needs and abilities during the course of treatment.}, language = {en} } @article{WinterMuellerHoffmannetal.2010, author = {Winter, Corinna and M{\"u}ller, Carsten and Hoffmann, Christiane and Boos, Joachim and Rosenbaum, Dieter}, title = {Physical activity and childhood cancer}, series = {Pediatric Blood \& Cancer}, volume = {54}, journal = {Pediatric Blood \& Cancer}, number = {4}, doi = {10.1002/pbc.22271}, pages = {501 -- 510}, year = {2010}, abstract = {This review provides a survey of studies investigating physical activity and exercise interventions in patients during tumor treatment and survivors of childhood cancer. PubMed and Medline databases were searched using relevant terms. References of selected papers were tracked. A total of 28 studies could be identified. Seventeen studies investigated physical activity, 11 studies determined the effect of activity enhancing interventions during and after therapy. Even though most studies showed limitations and results were not consistent, considerably reduced physical activity is highly probable in patients during and after therapy. Studies on interventions provided promising results and revealed challenges to be faced. Pediatr Blood Cancer}, language = {en} } @article{MuellerWinterKleinetal.2010, author = {M{\"u}ller, Carsten and Winter, Corinna and Klein, Dieter and Fuchs, Katharina and Schmidt, Carolin and Schulte, Tobias L. and Bullmann, Viola and Rosenbaum, Dieter}, title = {Objective assessment of brace wear times and physical activities in two patients with scoliosis}, series = {Biomedizinische Technik}, volume = {55}, journal = {Biomedizinische Technik}, number = {2}, doi = {10.1515/BMT.2010.026}, pages = {117 -- 120}, year = {2010}, abstract = {Conservative treatment of adolescent idiopathic scoliosis consists of therapeutic exercise and the application of braces. The effectiveness of bracing mainly depends on patient compliance, which can be determined by means of temperature sensors. This methodological paper describes the feasibility of objectively determining compliance and daily physical activities before and during conservative scoliosis treatment, being a relevant indicator for quality of life in children and adolescents. One patient with low compliance (61.4±24.9\%) reduced her activity level during bracing by 50.1\%, whereas another patient with a satisfactory compliance (85.7±19.5\%) increased her daily activity level by 33.7\% during conservative treatment.}, language = {en} } @article{MuellerWinterBoosetal.2014, author = {M{\"u}ller, Carsten and Winter, Corinna and Boos, Joachim and Gosheger, Georg and Hardes, Jendrik and Vieth, Volker and Rosenbaum, Dieter}, title = {Effects of an exercise intervention on bone mass in pediatric bone tumor patients}, series = {International Journal of Sports Medicine}, volume = {35}, journal = {International Journal of Sports Medicine}, number = {08}, doi = {10.1055/s-0033-1358475}, pages = {696 -- 703}, year = {2014}, abstract = {The aim was to evaluate the effects of additional exercises during inpatient stays on bone mass in pediatric bone tumor patients. 21 patients were non-randomly allocated either to the exercise group (n=10) or the control group (n=11). DXA of the lumbar spine, the non-affected femur and both calcanei was performed after completion of neoadjuvant chemotherapy (baseline), as well as 6 and 12 months after baseline. Bone mineral content (BMC), bone mineral density (BMD) and height-corrected lumbar spine Z-scores were determined. Group changes after 6 and 12 months were compared by covariance analyses. Additionally, daily physical activities (PA) were assessed by means of accelerometry. After adjusting for initial age, height and weight, mean reductions in lumbar spine and femoral BMC were lower in the exercise group (not significant). Effect sizes during the observational period for lumbar spine and femur BMC were generally small (partial η²=0.03). The exercise group demonstrated substantially higher PA levels in terms of gait cycles per day, per hour and moderate PA (activities above 40 gait cycles per minute). Additional exercises for bone tumor patients are feasible during hospitalization. Though the intervention did not influence BMC, it appeared beneficial regarding PA promotion with respect to volume and intensity.}, language = {en} } @article{MuellerKrauthGerssetal.2016, author = {M{\"u}ller, Carsten and Krauth, Konstantin A. and Gerß, Joachim and Rosenbaum, Dieter}, title = {Physical activity and health-related quality of life in pediatric cancer patients following a 4-week inpatient rehabilitation program}, series = {Supportive Care in Cancer}, volume = {24}, journal = {Supportive Care in Cancer}, doi = {10.1007/s00520-016-3198-y}, pages = {3793 -- 3802}, year = {2016}, abstract = {Abstract Purpose Chronic health conditions and impaired quality of life are commonly experienced in childhood cancer survivors. While rehabilitation clinics support patients in coping with the disease, studies evaluating an inpatient rehabilitation program on promoting physical activity (PA) and health-related quality of life (HRQoL) are missing. Methods A 4-week inpatient rehabilitation program was prospectively evaluated. One hundred fifty patients with leukemia or lymphoma (N = 86), brain tumors (N = 38), and sarcomas (N = 26) were enrolled on average 17 months after cessation of acute medical treatment. PA amount and cadence (indicating the intensity of walking activity) using the StepWatch™ 3 Activity Monitor and HRQoL global and physical well-being scores using the KINDL® questionnaire were assessed before, immediately after, and 6 and 12 months following the program and analyzed using multiple linear mixed models. Results Significant effects on PA were only found at 12-month follow-up for amount and cadence variables (all p < 0.05). While leukemia and lymphoma patients revealed the highest PA level throughout the study, rehabilitation effects were more pronounced for cadence variables in brain tumor and sarcoma patients. The rehabilitation program had immediate (t = 4.56, p < 0.001) and sustainable effects on HRQoL global scores (6-month follow-up, t = 4.08, p < 0.001; 12-month follow-up, t = 3.13, p < 0.006). Conclusions Immediate and sustainable increases in HRQoL indicate that a 4-week rehabilitation program is beneficial for improving psychosocial well-being, while the significant increase in PA levels could be related to general recovery as well. The lack of a control group hampers the evaluation of the rehabilitation program on promoting PA levels in pediatric cancer patients.}, language = {en} } @article{TanJetzkeVergeldetal.2020, author = {Tan, Shu Ling and Jetzke, Malte and Vergeld, Vera and M{\"u}ller, Carsten}, title = {Independent and Combined Associations of Physical Activity, Sedentary Time, and Activity Intensities With Perceived Stress Among University Students: Internet-Based Cross-Sectional Study}, series = {JMIR Public Health and Surveillance}, volume = {6}, journal = {JMIR Public Health and Surveillance}, number = {4}, doi = {10.2196/20119}, pages = {1 -- 14}, year = {2020}, abstract = {Background: Mental health is an emerging topic on university campuses, with students reporting higher levels of psychological distress than the general population of the same age. Increasing physical activity and reducing sedentary time have been proved promising measures to promote mental health in the general population. However, to derive and implement effective measures to promote mental health among university students, further exploration of the associations between physical activity, sedentary time, and perceived stress in this specific setting is needed. Objective: This study aims to identify associations between physical activity, sedentary time, and perceived stress after controlling for sociodemographic and behavioral variables among university students in Germany. We hypothesize that perceived stress is inversely related to physical activity and positively associated with sedentary time. Furthermore, we hypothesize that combined associations of concurrently high physical activity and low sedentary time on perceived stress are stronger compared with either alone and that the association between physical activity and perceived stress depends on activity intensity. Methods: We conducted cross-sectional analyses from a large-scale internet-based student health survey (n=4189; response rate=10.0\%). Physical activity, sedentary time, and engaging in moderate and vigorous activity intensities were assessed using the International Physical Activity Questionnaire Short Form with categorization into low, intermediate, and high levels. We measured perceived stress using the 10-item Perceived Stress Scale (range 0-40). Results: The results indicate that higher physical activity and lower sedentary time are associated with reduced levels of perceived stress. Following adjustment for gender, BMI, income, fruit and vegetable intake, alcohol consumption, and sleep quality, perceived stress scores were lower for students reporting high physical activity levels and low sedentary time compared with the least active and highly sedentary students (Perceived Stress Scale -2.2, 95\% CI -2.9 to -1.5, P<.001 for physical activity and -1.1, CI 95\% -1.7 to -0.5, P<.001 for sedentary time). Combined associations with perceived stress revealed that students concurrently reporting high total physical activity and low sedentary time reported the lowest perceived stress scores of all possible combinations following adjustment for confounders (Perceived Stress Scale -3.5, CI 95\% -4.6 to -2.5, P<.001 compared with students reporting low physical activity levels and concurrently high sedentary time). Associations between vigorous physical activities and perceived stress were not stronger compared with moderate activity intensities. Conclusions: Self-reported physical activity and low sedentary time are favorably associated with perceived stress, while the intensity of physical activities seems to be of minor importance. These results help to effectively implement health-promoting measures on campus among university students through increasing physical activity and reducing sedentary time.}, language = {en} }